Herbicidal 3-[[(4,6-dimethoxypyrimidine-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,5-dimethyl-1H-pyrazole-4-carboxylic acids, ethyl esters

ABSTRACT

Pyrazole sulfonylureas are useful as pre- and post-emergence herbicides. Typical of this group is 3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,5-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester.

BACKGROUND OF THE INVENTION

This invention relates to novel pyrazole sulfonylureas which are useful as pre- and post-emergence herbicides. The compounds of this invention and their agriculturally suitable salts, are useful as agricultural chemicals such as herbicides.

U.S. Pat. Nos. 4,169,719 and 4,127,405 disclose herbicidal benzene and thiophene sulfonamides.

U.S. Pat. No. 4,435,206 discloses herbicidal pyridine sulfonamides.

U.S. Pat. No. 4,420,325 discloses benzyl sulfonylureas such as: ##STR1##

EP-A-No.87780 (published Sept. 7, 1983), filed by Nissan Chemical Industries discloses pyrazole sulfonamides of the general formula shown below. ##STR2## wherein A is H, C₁ -C₈ alkyl or optionally substituted phenyl;

B and C are independently H, halogen, NO₂, C₁ -C₈ alkyl, CO₂ R, etc.;

D is H or C₁ -C₈ alkyl;

Z is CH or N; and

X and Y are methyl, methoxy, etc.

The presence of undesired vegetation causes substantial damage to useful crops, especially agricultural products that satisfy mans' basic food and fiber needs, such as cotton, rice, corn, wheat and the like. The current population explosion and concomitant world food and fiber shortage demand improvements in the efficiency of producing these crops. Preventing or minimizing loss of a portion of such valuable crops by killing or inhibiting the growth of undesired vegetation is one way of improving this efficiency.

A wide variety of materials useful for killing or inhibiting (controlling) the growth of undesired vegetation is available; such materials are commonly referred to as herbicides.

SUMMARY OF THE INVENTION

This invention relates to novel compounds of Formula I, agriculturally suitable compositions containing them and their method-of-use as pre-emergent or post-emergent herbicides or as plant growth regulants. ##STR3## wherein ##STR4## R is H or CH₃ ; R₁ is H, C₁ -C₃ alkyl, CO₂ R₁₅, SO₂ NR₁₆ R₁₇ or SO₂ R₁₈ ;

R₂ is H or CH₃ ;

R₃ is H or CH₃ ;

R₄ is H or CH₃ ;

R₅ is H, CH₃, Cl, Br, CO₂ R₁₅, C(O)NR₁₆ R₁₇, SO₂ NR₁₆ R₁₇,SO₂ N(OCH₃)CH₃, SO₂ R₁₈ or NO₂ ;

R₆ is H, C₁ -C₃ alkyl, CO₂ R₁₅, SO₂ NR₁₆ R₁₇ or SO₂ R₁₈ ;

R₇ is H or CH₃ ;

R₈ is CO₂ R₁₅, C(O)NR₁₆ R₁₇, SO₂ NR₁₆ R₁₇, SO₂ N(OCH₃)CH₃, SO₂ R₁₈ or NO₂ ;

R₉ is H, C₁ -C₃ alkyl or phenyl;

R₁₀ is CO₂ R₁₅, C(O)NR₁₆ R₁₇, SO₂ NR₁₆ R₁₇, SO₂ N(OCH₃)CH₃, SO₂ R₁₈ or NO₂ ;

R₁₁ is H or CH₃ ;

R₁₂ is H, CO₂ R₁₅, C(O)NR₁₆ R₁₇, SO₂ NR₁₆ R₁₇, SO₂ N(OCH₃)CH₃, SO₂ R₁₈ or NO₂ ;

R₁₃ is H, CO₂ R₁₅, C(O)NR₁₆ R₁₇, SO₂ NR₁₆ R₁₇, SO₂ N(OCH₃)CH₃, SO₂ R₁₈ or NO₂ ;

R₁₄ is H or CH₃ ;

R₁₅ is C₁ -C₂ alkyl;

R₁₆ is H or C₁ -C₂ alkyl;

R₁₇ is H or C₁ -C₂ alkyl;

R₁₈ is C₁ -C₂ alkyl;

R₁₉ is H, CH₃, Cl, Br, NO₂, C₁ -C₂ alkylthio or C₁ -C₂ alkylsulfonyl;

A is ##STR5## X is CH₃, OCH₃, Cl, Br, OCH₂ CF₃ or OCHF₂ ; Y is C₁ -C₃ alkyl, CH₂ F, cyclopropyl, C.tbd.CH, OCH₃, OC₂ H₅, CH₂ OCH₃, NH₂, NHCH₃, N(CH₃)₂, OCH₂ CH₂ F, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CR(OCH₃)₂, ##STR6## CR(OCH₂ CH₃)₂ or OCF₂ H; Z is CH or N;

X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H;

Y₁ is O or CH₂ ;

X₂ is CH₃, C₂ H₅ or CH₂ CF₃ ;

Y₂ is OCH₃, OC₂ H₅, SCH₃, SC₂ H₅, OCF₂ H, SCF₂ H, CH₃ or CH₂ CH₃ ;

X₃ is CH₃ or OCH₃ ;

Y₃ is H or CH₃ ;

provided that

(1) when X is Cl or Br, then Z is CH and Y is OCH₃, OC₂ H₅, NHCH₃, N(CH₃)₂ or OCF₂ H;

(2) R₅ and R₆ are not simultaneously H;

(3) when R₆ is other than H or C₁ -C₃ alkyl, then R₅ must be H;

(4) R₁₂ and R₁₃ are not simultaneously H;

(5) when R₁₂ is other than H, then R₁₃ must be H;

(6) when X or Y is OCF₂ H, then Z is CH;

(7) R₅ and R₁₉ are not simultaneously H; and

(8) when J is J-8 or J-11 then R₅ is other than H.

Preferred for their higher herbicidal activity, greater plant growth regulant activity and/or more favorable ease of synthesis are:

(1) Compounds of Formula I where

R is H;

A is A-1;

X is CH₃ or OCH₃ ; and

Y is C₁ -C₂ alkyl or C₁ -C₂ alkoxy.

(2) Compounds of Preferred 1 where J is J-1.

(3) Compounds of Preferred 2 where J is J-4.

(4) Compounds of Preferred 3 where J is J-5.

(5) Compounds of Preferred 4 where J is J-6.

Specifically preferred for their highest herbicidal activity, greatest plant growth regulant activity and/or more favorable ease of synthesis are:

3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,5-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester, m.p. 180°-183° C.; and

5-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,3-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester, m.p. 190° C.

DETAILED DESCRIPTION OF THE INVENTION Synthesis

The compounds of Formula I can be prepared by one or more of the methods described below in Equations 1, 2, 3 and 4.

As shown in Equation 1, compounds of Formula I can be prepared by reacting a sulfonyl isocyanate of Formula II with an appropriate heterocyclic amine of Formula III. J, R and A are as previously defined. ##STR7##

The reaction is carried out at 25° to 100° C. in an inert, aprotic solvent such as methylene chloride or xylene for 0.5 to 24 hours as taught in U.S. Pat. No. 4,127,405.

Compounds of Formula I, where R₁, R₅, R₆, R₈, R₁₀, R₁₂ and R₁₃ of J are other than CO₂ R₁₅, can be prepared by reacting the sulfonamides of Formula IV with an appropriate methyl carbamate of Formula V in the presence of at least an equimolar amount of trimethylaluminum, as shown in Equation 2. ##STR8##

The reaction is carried out at 25° to 40° C. in a solvent such as methylene chloride for 10 to 96 hours under an inert atmosphere as taught in EPO No. 84,244 (published July 27, 1983). The required carbamates V are prepared by reacting the corresponding amines III with dimethylcarbonate or methyl chloroformate in the presence of a strong base.

Alternatively, compounds of Formula I, can be prepared by reacting a sulfonylcarbamate of Formula VI with an appropriate amine of Formula III, as shown in Equation 3. ##STR9##

The reaction is carried out at 50° to 100° C. in a solvent such as dioxane for 0.5 to 24 hours as taught in EPO publication No. 44807. The required carbamates VI are prepared by reacting the corresponding sulfonamides IV with diphenylcarbonate in the presence of a strong base.

Additionally, compounds of Formula I, can be prepared by reacting a sulfonamide of Formula IV with an appropriate heterocyclic phenyl carbamate of Formula VII, in the presence of a nonnucleophilic base, such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as shown below in Equation 4. ##STR10##

The reaction is carried out at 20° to 100° C. in an inert solvent, such as dioxane, for 0.5 to 24 hours by the methods taught in EPO publication No. 44807. The required carbamates, VII, are prepared by reacting the corresponding heterocyclic amines, III, with phenylchloroformate in the presence of a base.

The intermediate sulfonyl isocyanates of Formula II in Equation 1 can be prepared as shown in Equations 5 and 6.

As shown in Equation 5, sulfonyl isocyanates of Formula II where J is other than J₁, J₂ and J₃ can be prepared by the reaction of sulfonamides of Formula IV with phosgene, in the presence of n-butyl isocyanate and a tertiary amine catalyst, such as diazabicyclo[2.2.2]octane (DABCO®), at reflux in a solvent such as xylene by the method of U.S. Pat. No. 4,238,621. ##STR11##

The sulfonyl isocyanates can also be prepared from the sulfonamides by a two step procedure involving (a) reacting the sulfonamides with n-butyl isocyanate in the presence of a base such as K₂ CO₃ at reflux in an inert solvent such as 2-butanone forming a n-butyl sulfonylurea; and (b) reacting this compound with phosgene and a tertiary amine catalyst at reflux in xylene solvent. The method is similar to a procedure taught by Ulrich and Sayigh, Newer Methods of Preparative Organic Chemistry, Vol. VI, p. 223-241, Academic Press, New York and London, W. Foerst Ed.

Alternatively, as shown in Equation 6, the sulfonyl isocyanates of Formula II can be prepared by reacting the corresponding sulfonyl chlorides VIII with cyanic acid salts. ##STR12##

The reaction is carried out at 25° to 100° C. in an inert aprotic solvent such as acetonitrile for 0.5-24 hours in the presence of phosphorus pentoxide and an alkali metal salt such as lithium iodide according to the teachings of Japanese Patent No. 76/26,816 (Chem. Abst., 85:77892e (1976)).

As shown in Equation 7, sulfonamides of Formula IV can be prepared from the corresponding sulfonyl chlorides of Formula VIII by contacting with either anhydrous or aqueous ammonia. ##STR13##

The preparation of sulfonamides from sulfonyl chlorides is widely reported in the literature, for reviews see: F. Hawking and J. S. Lawrence, "The Sulfonamides," H. K. Lewis and Co., London, 1950 and E. H. Northey, "The Sulfonamides and Allied Compounds," Reinhold Publishing Corp., New York, 1948.

The requisite methylsulfonyl chlorides of Formula VIII may be synthesized from appropriately substituted benzylic type chlorides or benzylic type bromides, IX, by the two-step sequence of reactions outlined below in Equation 8 and Equation 9. ##STR14## wherein L is Cl or Br; and

J is as previously defined. ##STR15##

Equation 8(a)

The conversion of alkyl halides to isothiouronium salts is well precedented in the chemical literature. For relevant examples, see T. B. Johnson and J. M. Sprague, J. Am. Chem. Soc., 58, 1348 (1936); ibid, 59, 1837 and 2439 (1937); ibid, 61, 176 (1939). In a typical procedure, a benzylic type halide of Formula IX is treated with thiourea in protic solvents such as methanol or ethanol, or aprotic solvents such as methylene chloride or benzene. Temperatures of 40°-80° over one-half to 24 hours are typically required to complete the reaction. The product salts, X, are isolated by cooling and filtration or by concentration to remove the solvent. The salts, X, are generally sufficiently pure to be carried on directly to step (8b) without further purification.

Equation 8(b)

The oxidative chlorination of isothiouronium salts to afford sulfonyl chlorides is most efficiently carried out according to the procedure of Johnson as described in J. Am. Chem. Soc., 61, 2548 (1939). Thus, the salts of Formula X (L=chlorine or bromine) are dissolved or suspended in water or aqueous acetic acid and treated with at least three equivalents of chlorine at temperatures between 5°-20° C. When the hydrobromide salts X (L=bromine) are used, it is sometimes advantageous to exchange the bromide ion for nitrate ion before chlorination by treatment with an aqueous solution of one equivalent of silver nitrate; the precipitated silver bromide is removed by filtration and the filtrate treated as described above. The product sulfonyl chlorides are isolated either by simple filtration or extraction into a suitable solvent such as methylene chloride or n-butyl chloride followed by drying and evaporation of the combined organic extracts. No further purification of the sulfonyl chlorides, VIII, is necessary.

The conversion of a benzylic type chloride or bromide of Formula IX to a sulfonic acid salt of Formula XI as shown in Equation 9(a) is well known in the art. For a review, see Gilbert "Sulfonation and Related Reactions" Interscience Publishers, New York, 1965, pp. 136-148 and 161-163. The methods of conversion of a sulfonic acid salt of Formula XI to a sulfonyl chloride of Formula VIII is well known to those skilled in the art.

Benzylic type bromides of Formula IXa (L=bromine) may be prepared as shown below in Equation 10 by treating the appropriate methyl imidazole or pyrazole XII, with N-bromosuccinimide (NBS). ##STR16## wherein Q is as previously defined.

The reaction represented in Equation 10 can be most conveniently effected by heating a solution of the methyl imidazole or pyrazole derivatives, XII, and N-bromosuccinimide in a suitable solvent such as carbon tetrachloride at reflux temperature. A free radical catalyst such as azoisobutyronitrile (AIBN) or benzoyl peroxide is usually employed to initiate this reaction. When bromination is complete, the cooled reaction mixture is filtered to remove the by-product succinimide and the filtrate is concentrated in vacuo. The benzylic type bromides of Formula IXa are often obtained in a sufficiently pure condition for further transformations. If not, they can be purified by vacuum distillation or column chromatography.

Benzylic type chlorides of Formula IXb (L=chlorine) may be most efficiently synthesized by one of two methods, both of which are well known in the chemical literature. First, benzylic type chlorides, IXb, can be prepared from the appropriate methyl imidazole or pyrazole type derivatives of Formula XII by reaction with N-chlorosuccinimide (NCS). This reaction is depicted below in Equation 11. ##STR17##

The reaction of Equation 11 can be carried out in a manner analogous to that described for the NBS bromination in Equation 10.

In compounds of Formula XII where J is J-1, J-2 or J-3, ring halogenation may occur together with benzylic-type halogenation in Equations 10 and 11. Subsequent removal of the ring halogen after conversion to the desired sulfonamide IV may be carried out by methods known in the art.

Alternatively, benzylic type chlorides of Formula IXb may be prepared from the appropriate benzylic type alcohols of Formula XIII as shown below in Equation 12. ##STR18##

There exists a variety of well known methods for converting alkyl alcohols to the corresponding chlorides. One of the most common procedures involves reaction of the alcohol with thionyl chloride either alone or in the presence of a trace of a suitable base such as pyridine. For relevant examples, see the following references: H. Gilman and J. E. Kirby, J. Am. Chem. Soc., 51, 3475 (1929); H. Gilman and A. P. Hewlett, Rec. Trav. Chim., 51, 93 (1932); and M. S. Newman, J. Am. Chem. Soc., 62, 2295 (1940).

The requisite heterocyclic methanols of Formula XIII may be prepared by reduction of an appropriately substituted imidazole, pyrazole, pyridinyl or thienyl carboxylic acid. The reduction is best effected by treatment of an appropriately substituted imidazole or pyrazole carboxylic acid with a suitable reducing agent such as diborane in tetrahydrofuran solvent. For a description of this procedure, refer to H. C. Brown, J. Org. Chem., 38, 2786 (1973).

Substituted heterocyclic carboxylic acid derivatives, the functionalized heterocyclic methanols of Formula XIII and heterocyclic methyl compounds of Formula XII can be prepared by any of several possible synthetic routes known to one skilled in the art.

The heterocyclic amines of Formula III can be prepared by methods known in the literature or simple modifications thereof, by those skilled in the art. For instance, EP-A No. 84,224 (published July 27, 1983) and W. Braker et al, J. Am. Chem. Soc. 1947, 69, 3072 describe methods for preparing aminopyrimidines and triazines substituted by acetal groups. Also, South African Patent Application Nos. 825,045 and 825,671 describe methods for preparing aminopyrimidines and triazines substituted by haloalkyl or haloalkylthio groups such as OCH₂ CH₂ F, OCH₂ CF₃, SCF₂ H, and OCF₂ H among other groups. South African Patent Application No. 837,434 (published Oct. 5, 1983) describes methods for the synthesis of cyclopropylpyrimidines and triazines substituted by such groups as alkyl, haloalkyl, alkoxy, haloalkoxy, alkylamino, dialkylamino, and alkoxyalkyl.

The 5,6-dihydrofuro[2.3-d]pyrimidin-2-amines, and the cyclopenta[d]pyrimidin-2-amines, of formula III, where A is A-2, and the 6,7-dihydro-5H-pyrano[2.3-d]pyrimidin-2-amines, of formula III, where A is A-3, can be prepared as described in EP-A No. 15,863. The furo[2.3-d]-pyrimidin-2-amines, of formula III, where A is A-4, are described in EP-A No. 46,677. Heterocycles of formula III, where A is A-5, may be prepared as described in EP-A No. 73,562. Heterocycles of Formula III, where A is A-6, may be prepared by methods taught in EP-A No. 94,260.

In addition, general methods for preparing aminopyrimidines and triazines have been reviewed in the following publications.

• "The Chemistry of Heterocyclic Compounds", a series published by Interscience Publishers, Inc., New York and London;

• "Pyrimidines", Vol. 16 of the same series by D. J. Brown;

• "s-Triazines and Derivatives", Vol. 13 of the same series by E. M. Smolin and L. Rappaport; and

• F. C. Schaefer, U.S. Pat. No. 3,154,547 and K. R. Huffman and F. C. Schaefer, J. Org. Chem., 28, 1812 (1963), which describe the synethsis of triazines.

Agriculturally suitable salts of compounds of Formula I are also useful herbicides and can be prepared in a number of ways known to the art. For example, metal salts can be made by contacting compounds of Formula I with a solution of an alkali or alkaline earth metal salt having a sufficiently basic anion (e.g., hydroxide, alkoxide, carbonate or hydride). Quaternary amine salts can be made by similar techniques.

Salts of compounds of Formula I can also be prepared by exchange of one cation for another. Cationic exchange can be effected by direct contacting of an aqueous solution of a salt of a compound of Formula I (e.g., alkali metal or quaternary amine salt) with a solution containing the cation to be exchanged. This method is most effective when the desired salt containing the exchanged cation is insoluble in water, e.g., a copper salt, and can be separated by filtration.

Exchange may also be effected by passing an aqueous solution of a salt of a compound of Formula I (e.g., an alkali metal or quaternary amine salt) through a column packed with a cation exchange resin containing the cation to be exchanged. In this method, the cation of the resin is exchanged for that of the original salt and the desired product is eluted from the column. This method is particularly useful when the desired salt is water-soluble, e.g., a potassium, sodium or calcium salt.

Acid addition salts, useful in this invention, can be obtained by reacting a compound of Formula I with a suitable acid, e.g., p-toluenesulfonic acid, trichloroacetic acid or the like.

The preparation of the compounds of this invention is illustrated by the following examples.

EXAMPLE 1 Ethyl 5-(chloromethyl)-1,3-dimethyl-1H-pyrazole-4-carboxylate

To 5.3 g (26.8 mmol) of 4-ethoxycarbonyl-5-(1-hydroxymethyl)-1,3-dimethylpyrazole prepared by the method of S. Gelin, et al., J. Heterocyclic Chem., 16, (1979) 1117-20, was added 1.95 ml (26.8 mmol) of thionyl chloride, dropwise. Gas evolution and an exotherm occurred. The solution was cooled with an ice bath. After ten minutes the solution gave a solid, m.p. 81°-83° C., ¹ H NMR (90 MHz, CDCl₃): δ 1.4 (t, OCCH₃, 3H); 2.65 (s, CH₃, 3H); 4.2 (s, NCH₃, 3H); 4.4 (q, OCH₂ C, 2H); 5.2 (s, CH₂ Cl, 2H).

This material was combined with the product of a second reaction (5.0 g of 4-ethoxycarbonyl-5-(1-hydroxymethyl)-1,3-dimethylpyrazole and 1.93 ml thionyl chloride), dissolved in dichloromethane, washed with brine, dried (MgSO₄) and concentrated to give 10.7 g of a solid, mp. 81°-83° C.

EXAMPLE 2 Ethyl 5-[[(amino)(imino)methyl]thiomethyl]-1,3-dimethyl-1H-pyrazole-4-carboxylate

A solution under nitrogen was prepared from 10.7 g of the compound produced in Example 1 and 3.95 g of thiourea in 200 ml of ethanol. After refluxing the solution four hours, it was allowed to stir at room temperature overnight. The solvent was removed under reduced pressure. Then, the residue was triturated with hexane to give 16 g of solid (wet weight), m.p. 175°-180° C.

EXAMPLE 3 Ethyl 5-methanesulfonamide-1,3-dimethyl-1H-pyrazole-4-carboxylate

To 14 g of the compound produced in Example 2, dissolved in 90 ml of water at 5° C. was added 10 ml of chlorine dropwise. The rate of addition was monitored so that the temperature did not exceed 20° C. A precipitate formed. The aqueous portion was decanted off and the residue was dissolved in dichloromethane, washed with a saturated sodium bicarbonate solution, dried (MgSO₄) and concentrated. The residue was dissolved in 100 ml of THF. To a 75 ml portion of the THF solution, cooled to 5° C., was added 1.5 ml of concentrated ammonium hydroxide solution in 10 ml of THF. A suspension formed, which was stirred for six hours. The reaction mixture was filtered and the mother liquor was concentrated under reduced pressure. The residue, triturated with ethyl acetate-diethyl ether (40:60) gave 3.0 g of a light yellow solid, m.p. 135°-138° C.; ¹ H NMR (90 MHz, d₆ -DMSO): δ 1.2 (t, CH₃, 3H); 2.3 (s, CH₃, 3H); 3.8 (s, NCH₃, 3H); 4.2 (q, OCH₂, 2H); 4.8 (s, CH₂ SO₂, 2H); 7.1 (bs, NH₂, 2H).

EXAMPLE 4 Ethyl 5-[[[[4,6-dimethoxypyrimidin-2-yl]aminocarbonyl]aminosulfonyl]methyl]-1,3-dimethyl-1H-pyrazole-4-carboxylate

In a dry flask under nitrogen was stirred 0.33 g of the sulfonamide from Example 3 and 0.35 g of phenyl (4,6-dimethoxypyrimidin-2-yl)carbamate and 30 ml of dry acetonitrile. Then 0.19 ml of 1,8-diazabicyclo[5.4.0]undec-7-ene was added via syringe and the solution stirred overnight. Then 50 ml of water was added, followed by a dropwise addition of 1 NHCl until a precipitate formed. The suspension was filtered. The filtrant, after being triturated with diethyl ether, gave 0.4 g of solid, m.p. 190° C.; 1R (Nujol) 1711 and 1680 (C═O) cm⁻¹ ; ¹ H NMR (200 MHz, CDCl₃): δ 1.25 (t, CH₃, 3H); 2.38 (s, CH₃, 3H); 3.80 (s, OCH₃, 6H); 3.94 (s, NCH₃, 3H); 4.15 (q, OCH₂, 2H); 5.23 (s, CH₂ SO₂, 2H); 5.71 (s, bs, CH, 1H); 7.35 (bs, NH, 1H) and 12.4 (bs, NH, 1H).

The invention is further exemplified, but not limited to, the compounds in Tables I-XXII. The compounds depicted in these tables may be prepared by methods described in Examples 1-4, or by modifications thereof apparent to those skilled in the art.

                                      TABLE I                                      __________________________________________________________________________      ##STR19##                                                                     R.sub.1    R.sub.2                                                                           R.sub.3                                                                           X     Y        Z  m.p. (°C.)                           __________________________________________________________________________     H          H  H  CH.sub.3                                                                             CH.sub.3 CH                                             H          H  H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             CH.sub.3   H  H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             CH.sub.3   H  H  CH.sub.3                                                                             CH.sub.3 N                                              CH.sub.3   H  H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                              CH.sub.2 CH.sub.3                                                                         H  H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              CH.sub.2 CH.sub.2 CH.sub.3                                                                H  H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      CH                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                H  H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                H  H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             CH.sub.2 CH.sub. 2 CH.sub.3                                                               H  H  CH.sub.3                                                                             CH.sub.3 N                                              CH(CH.sub.3).sub.2                                                                        H  H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.3                                                                         H  H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.3                                                                         H  H  Br    OCH.sub.3                                                                               CH                                             CO.sub.2 CH.sub.3                                                                         H  H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             CO.sub.2 CH.sub.3                                                                         H  H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             CO.sub.2 CH.sub.3                                                                         H  H  CH.sub.3                                                                             CH.sub.3 N                                              CO.sub.2 CH.sub.3                                                                         H  H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                H  H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              C(O)N(CH.sub.3).sub.2                                                                     H  H  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                             CO.sub.2 CH.sub.2 CH.sub.3                                                                H  H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                                H  H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     H  H  CH.sub.3                                                                             CH.sub.3 N                                              SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H  H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                              SO.sub.2 CH.sub.3                                                                         H  H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              SO.sub.2 CH.sub.3                                                                         H  H  CH.sub.3                                                                             CH.sub.2 F                                                                              CH                                             SO.sub.2 CH.sub.3                                                                         H  H  CH.sub.3                                                                             OCH.sub. 3                                                                              CH                                             SO.sub.2 CH.sub.3                                                                         H  H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             SO.sub.2 CH.sub.3                                                                         H  H  Cl    OCH.sub.3                                                                               CH                                             SO.sub.2 CH.sub.2 CH.sub.3                                                                H  H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             H          CH.sub.3                                                                          H  CH.sub.3                                                                             CH.sub.3 CH                                             H          CH.sub.3                                                                          H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             CH.sub.3   CH.sub.3                                                                          H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             CH.sub.3   CH.sub.3                                                                          H  CH.sub.3                                                                             CH.sub.3 N                                              CH.sub.3   CH.sub.3                                                                          H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                              CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      CH                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          H  CH.sub.3                                                                             CH.sub.3 N                                              CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                          H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3 CH                                             CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          H  CH.sub. 3                                                                            OCH.sub.3                                                                               CH                                             CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             C(O)N(H)C.sub.2 H.sub.5                                                                   CH.sub.3                                                                          H  CH.sub.3                                                                             CH.sub.3 N                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          H  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                             CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                          H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                          H  CH.sub.3                                                                             CH.sub.3 N                                              SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                          H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                              SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          H  CH.sub.3                                                                             CH.sub.3 CH                                             SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          H  Cl    OCH.sub.3                                                                               CH                                             SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             H          H  CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 CH                                             H          H  CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             CH.sub.3   H  CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             CH.sub.3   H  CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                              CH.sub.3   H  CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                              CH.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                          OCH.sub.3                                                                            Δ  N                                              CH.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      CH                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                              CH(CH.sub.3).sub.2                                                                        H  CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                              C(O)NH.sub.2                                                                              H  CH.sub.3                                                                          OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                       N                                              CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 CH                                             CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                              CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                             CO.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     H  CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                              SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H  CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.2 CH.sub.2 F                                                                    N                                              SO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              SO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                          OCHF.sub.2                                                                           CH.sub.3 CH                                             SO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             SO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             SO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                          Cl    OCH.sub.3                                                                               CH                                             SO.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             H          CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             CF.sub.3 CH                                             H          CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             CH.sub.3   CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub. 3                                                                              CH                                             CH.sub.3   CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             SCH.sub.3                                                                               N                                              CH.sub.3   CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                              CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      CH                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.2 CCH                                                                           CH                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                              CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.2 CH.sub.3 OCH.sub.3                                                            CH                                             CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                              C(O)N(C.sub.2 H.sub.5).sub.2                                                              CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                             CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                     CH                                             SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                              SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                              SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                              SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 CH                                             SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                             SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                             SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                          Cl    OCH.sub.3                                                                               CH                                             SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                       CH                                             __________________________________________________________________________

                                      TABLE II                                     __________________________________________________________________________      ##STR20##                                                                     R.sub.4                                                                           R.sub.5    R.sub.6    X     Y        Z  m.p. (°C.)                   __________________________________________________________________________     H  CH.sub.3   H          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  CH.sub.3   H          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  CO.sub.2 CH.sub.3                                                                         H          CH.sub.3                                                                             CH.sub.3 N                                      H  CO.sub.2 CH.sub.3                                                                         H          CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  CO.sub.2 CH.sub.3                                                                         H          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  CO.sub.2 CH.sub.3                                                                         H          CH.sub.3                                                                             OCF.sub.2 H                                                                             CH                                     H  CO.sub.2 CH.sub.3                                                                         H          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  CO.sub.2 CH.sub.3                                                                         H          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  CO.sub.2 CH.sub.2 CH.sub.3                                                                H          CH.sub.3                                                                             CH.sub.3 N                                      H  CO.sub.2 CH.sub.2 CH.sub.3                                                                H          CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      N                                      H  SO.sub.2 N(CH.sub.3).sub.2                                                                H          OCH.sub.3                                                                            NHCH.sub.3                                                                              N                                      H  SO.sub.2 N(CH.sub.3).sub.2                                                                H          CH.sub.3                                                                             CH.sub.3 CH                                     H  SO.sub.2 N(CH.sub.3).sub.2                                                                H          CH.sub.3                                                                             CCH      CH                                     H  SO.sub.2 N(CH.sub.3).sub.2                                                                H          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  SO.sub.2 N(CH.sub.3).sub.2                                                                H          CH.sub.3                                                                             CH.sub.3 N                                      H  SO.sub.2 N(CH.sub.3).sub.2                                                                H          CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     H          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             H          CH.sub.3                                                                             CH.sub.3 CH                                     H  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H          Br    OCH.sub.3                                                                               CH                                     H  SO.sub.2 CH.sub.3                                                                         H          CH.sub.3                                                                             CH.sub.3 N                                      H  SO.sub.2 CH.sub.3                                                                         H          CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  Cl         H          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  SO.sub.2 CH.sub.3                                                                         H          CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                       CH                                     H  SO.sub.2 CH.sub.3                                                                         H          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  SO.sub.2 CH.sub.3                                                                         H          OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                     CH                                     H  SO.sub.2 CH.sub.2 CH.sub.3                                                                H          Cl    OCH.sub.3                                                                               CH                                     H  SO.sub.2 CH.sub.2 CH.sub.3                                                                H          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  H          CH.sub.3   CH.sub.3                                                                             CH.sub.3 CH                                     H  CH.sub.3   CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  CH.sub.3   CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  CO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             CH.sub.3 N                                      H  CO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  CO.sub.2 CH.sub.3                                                                         CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  CO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             CH.sub.3 CH                                     H  CO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  CO.sub.2 CH.sub.3                                                                         CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3   CH.sub.3                                                                             CH.sub.3 N                                      H  CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      N                                      H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3   CH.sub.3                                                                             CH.sub.3 CH                                     H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3   CH.sub.3                                                                             CH.sub.3 N                                      H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3   CH.sub.3                                                                             CH.sub.3 CH                                     H  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3   CH.sub.3                                                                             OCH.sub.2 CHCH.sub.2                                                                    CH                                     H  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  SO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             CH.sub.3 N                                      H  SO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  SO.sub.2 CH.sub.3                                                                         CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  SO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                       CH                                     H  Br         CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  SO.sub.2 CH.sub.3                                                                         CH.sub.3   OCH.sub.3                                                                            OCH.sub. 3                                                                              CH                                     H  SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3   Cl    OCH.sub.3                                                                               CH                                     H  SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  H          CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                     H  CH.sub.3   CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  CH.sub.3   CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 N                                      H  CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                     H  CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            SCH.sub.3                                                                               CH                                     H  CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 N                                      H  CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub. 2 CH.sub.3                                                                     N                                      H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                               N                                      H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                     H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 N                                      H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                     H  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub. 2 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3 N                                      H  SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                       CH                                     H  SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                Cl    CH.sub.2 F                                                                              CH                                     H  SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          H          CH.sub.3   CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          CH.sub.3   CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          CH.sub.3   CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             CH.sub.3 N                                      CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               N                                      CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          CO.sub. 2 CH.sub.3                                                                        CH.sub.3   CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.3   OCH.sub.3                                                                            NH.sub.2 CH                                     CH.sub.3                                                                          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3   CH.sub.3                                                                             CH.sub.3 N                                      CH.sub.3                                                                          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      N                                      CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3   CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3   CH.sub.3                                                                             CH.sub.3 N                                      CH.sub.3                                                                          Br         CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               N                                      CH.sub.3                                                                          SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3   CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3   CH.sub.3                                                                             OCH.sub. 3                                                                              CH                                     CH.sub.3                                                                          SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             CH.sub.3 N                                      CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               N                                      CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                       CH                                     CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.3   OCF.sub.2 H                                                                          CH.sub.3 CH                                     CH.sub.3                                                                          SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3   Cl    OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          H          CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          CH.sub.3   CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          CH.sub.3   CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 N                                      CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                      CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 N                                      CH.sub.3                                                                          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      N                                      CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub. 2 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3 N                                      CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                      CH.sub.3                                                                          SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 N                                      CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                      CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                       CH                                     CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.2 CH.sub.2 F                                                                    CH                                     CH.sub.3                                                                          SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  H          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                       CH                                     H  H          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  H          CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  H          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 N                                      H  H          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  H          CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  H          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                     H  H          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             SCH.sub.3                                                                               CH                                     H  H          CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  H          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.2 CH.sub.2 CH.sub.3                                                              N                                      H  H          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  H          CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                     H  H          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3 CH                                     H  H          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  H          SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  H          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                       N                                      H  H          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  H          SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  H          SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             CH.sub.3 CH                                     H  H          SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  H          SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  H          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      N                                      H  H          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               N                                      H  H          SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      H  H          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 CH                                     H  H          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     H  H          SO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     H  H          Cl         OCH.sub.3                                                                            CH.sub. 2 CH.sub.3                                                                      CH                                     H  H          SO.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.2 CH.sub.2 OCH.sub.3                                                            CH                                     CH.sub.3                                                                          H          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          H          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          H          CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          H          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 N                                      CH.sub.3                                                                          H          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               N                                      CH.sub.3                                                                          H          CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          H          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          H          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          H          CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          H          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 N                                      CH.sub.3                                                                          H          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                      CH.sub.3                                                                          H          CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                     CH.sub.3                                                                          H          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          H          SO.sub.2 N(CH.sub.3).sub. 2                                                               CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          H          SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          H          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                       N                                      CH.sub.3                                                                          H          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                      CH.sub.3                                                                          H          SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          H          SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          H          SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          H          SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          H          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      N                                      CH.sub.3                                                                          H          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               N                                      CH.sub.3                                                                          H          SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               N                                      CH.sub.3                                                                          H          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 CH                                     CH.sub.3                                                                          H          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          H          SO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          H          SO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                       CH                                     CH.sub.3                                                                          H          SO.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          NO.sub.2   H          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                     CH.sub.3                                                                          NO.sub.2   CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                               N                                      CH.sub.3                                                                          NO.sub.2   CH.sub.3   OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                       N                                      __________________________________________________________________________

                                      TABLE III                                    __________________________________________________________________________      ##STR21##                                                                     R.sub.7                                                                           R.sub.8    X     Y        Z  m.p. (°C.)                              __________________________________________________________________________     H  CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 CH                                                H  CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               CH                                                H  CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                                H  CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 N                                                 H  CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               N                                                 H  CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               N                                                 H  CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                                H  C(O)N(CH.sub.3).sub.2                                                                     CH.sub.3                                                                             OCH.sub.3                                                                               CH                                                H  C(O)N(H)C.sub.2 H.sub.5                                                                   OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                                H  SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                       N                                                 H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                                 H  SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               N                                                 H  SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3 CH                                                H  SO.sub.2 N(CH.sub.3).sub.2                                                                Br    OCH.sub.3                                                                               CH                                                H  SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                                H  SO.sub.2 N(CH.sub.3)OCH.sub.3                                                             CH.sub.3                                                                             CH.sub.3 N                                                 H  SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      N                                                 H  SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               N                                                 H  SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 CH                                                H  SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               CH                                                H  SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                                H  SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 N                                                 H  SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               N                                                 H  SO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            SCH.sub.3                                                                               N                                                 H  NO.sub.2   CH.sub.3                                                                             CH.sub.3 CH                                                H  NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                               CH                                                H  NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                                H  NO.sub.2   Cl    OCH.sub.3                                                                               CH                                                H  NO.sub.2   OCH.sub.3                                                                            CH.sub.2 OCH.sub. 3                                                                     CH                                                CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 CH                                                CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               CH                                                CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                                CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 N                                                 CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               N                                                 CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.2 CH.sub.2 F                                                                    N                                                 CH.sub.3                                                                          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3 CH                                                CH.sub.3                                                                          CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                                CH.sub.3                                                                          CO.sub.2 CH.sub.2 CH.sub.3                                                                OCF.sub.2 H                                                                          OCH.sub.3                                                                               CH                                                CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                       N                                                 CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                               N                                                 CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               N                                                 CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3 CH                                                CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                               CH                                                CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                                CH.sub.3                                                                          SO.sub.2 N(CH.sub.3)OCH.sub.3                                                             CH.sub. 3                                                                            CH.sub.3 N                                                 CH.sub.3                                                                          SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      N                                                 CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               N                                                 CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 CH                                                CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               CH                                                CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                               CH                                                CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3 N                                                 CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                               N                                                 CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                               N                                                 CH.sub.3                                                                          NO.sub.2   CH.sub.3                                                                             CH.sub.3 CH                                                CH.sub.3                                                                          NO.sub.2   CH.sub.3                                                                             Δ  CH                                                CH.sub.3                                                                          NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                                CH.sub.3                                                                          NO.sub.2   Cl    OCH.sub.3                                                                               CH                                                CH.sub.3                                                                          NO.sub.2   OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                                CH.sub.3                                                                          NO.sub.2   OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                       CH                                                H  CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.2 F                                                                              CH                                                H  CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CCH      CH                                                H  CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CF.sub.3 CH                                                H  CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            NHCH.sub.3                                                                              CH                                                H  CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                       CH                                                H  CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.2 CHCH.sub.2                                                                    CH                                                H  CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CH(OCH.sub.2 CH.sub.3).sub.2                                                            CH                                                __________________________________________________________________________

                                      TABLE IV                                     __________________________________________________________________________      ##STR22##                                                                     R.sub.9                                                                               R.sub.10   R.sub.11                                                                          X    Y        Z  m.p. (°C.)                        __________________________________________________________________________     H      CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                            CH.sub.3 CH                                          H      CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                            OCH.sub.3                                                                               CH                                          H      CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                           OCH.sub.3                                                                               CH                                          H      CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                            CH.sub.3 N                                           H      CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                            OCH.sub.3                                                                               N                                           H      CO.sub.2 CH.sub.2 CH.sub.3                                                                H  OCH.sub.3                                                                           OCH.sub.3                                                                               N                                           H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                            CF.sub.3 CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                            OCH.sub.3                                                                               CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                      CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                               CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3 CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                               CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.2 CH.sub.2 OCH.sub.3                                                            CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3 N                                           CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                               N                                           CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               N                                           CH.sub.3                                                                              C(O)NH.sub.2                                                                              CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                      CH                                          CH.sub.3                                                                              C(O)NHCH.sub.3                                                                            CH.sub.3                                                                          OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                      CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3 CH                                                                      H  CH.sub.3                                                                            OCH.sub.3                                                                               CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3 CH                                                                      H  OCH.sub.3                                                                           OCH.sub.3                                                                               CH 198-200°                          CH.sub.3                                                                              CO.sub.2 CH.sub.3 CH                                                                      H  CH.sub.3                                                                            OCH.sub.3                                                                               N                                           CH.sub.3                                                                              CO.sub.2 CH.sub.3 CH                                                                      H  OCH.sub.3                                                                           OCH.sub.3                                                                               N  199-201°                          CH.sub.3                                                                              CO.sub.2 CH.sub.3 CH                                                                      H  Cl   OCH.sub.3                                                                               CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          OCF.sub.2 H                                                                         CH.sub.3 CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                               CH                                          CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               CH 190                                      CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3 N                                           CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                               N  183-184°                          CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               N  165-167°                          CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          Cl   OCH.sub.3                                                                               CH 140.5-144.5                              CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                      CH                                          CH.sub.2 CH.sub.2 CH.sub.3                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               N                                           CH.sub.2 CH.sub.2 CH.sub.3                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               CH                                          CH.sub.2 CH.sub.2 CH.sub.2                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                               CH                                          CH.sub.2 CH.sub.2 CH.sub.2                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                H  OCH.sub.3                                                                           CH.sub.2 F                                                                              CH                                          CH.sub.2 CH.sub.2 CH.sub.3                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                H  OCH.sub.3                                                                           OCH.sub.3                                                                               N                                           CH.sub.2 CH.sub.2 CH.sub.2                                                            CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                           OCH.sub.3                                                                               CH                                          CH.sub.2 CH.sub.2 CH.sub.3                                                            CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               N                                           C.sub.6 H.sub.5                                                                       CO.sub.2 Et                                                                               H  OCH.sub.3                                                                           OCH.sub.3                                                                               CH                                          C.sub.6 H.sub.5                                                                       CO.sub.2 Et                                                                               CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3 N                                           C.sub.6 H.sub.5                                                                       CO.sub.2 Et                                                                               CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                               N                                           C.sub.6 H.sub.5                                                                       CO.sub.2 Et                                                                               CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               N                                           C.sub.6 H.sub.5                                                                       CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3 CH                                          C.sub.6 H.sub.5                                                                       CO.sub.2 Et                                                                               CH.sub.3                                                                          CH.sub.3                                                                            SCH.sub.3                                                                               CH                                          C.sub.6 H.sub.5                                                                       CO.sub.2 Et                                                                               CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               CH                                          H      SO.sub.2 N(CH.sub.3).sub.2                                                                H  Br   OCH.sub.3                                                                               CH                                          H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H  OCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                      N                                           H      SO.sub.2 N(CH.sub.3)OCH.sub.3                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                               CH                                          H      SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub. 3                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                               CH                                          H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 F                                                                              N                                           H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                               N                                           H      NO.sub.2   CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               N                                           CH.sub.3                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                            CH.sub.3 CH                                          CH.sub.3                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                               CH                                          CH.sub.3                                                                              SO.sub.2 N(CH.sub.3)OCH.sub.3                                                             H  OCH.sub.3                                                                           CH(OCH.sub.3).sub.2                                                                     CH                                          CH.sub.3                                                                              SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3 N                                           CH.sub.3                                                                              NO.sub.2   H  CH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                      N                                           CH.sub.3                                                                              NO.sub.2   CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               N                                           CH.sub.2 CH.sub.2 CH.sub.3                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                            CH.sub.3 CH                                          CH.sub.2 CH.sub.2 CH.sub.3                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                               CH                                          CH.sub.2 CH.sub.2 CH.sub.3                                                            SO.sub.2 N(CH.sub.3)OCH.sub.3                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                               CH                                          CH.sub.2 CH.sub.2 CH.sub.3                                                            SO.sub.2 N(CH.sub.3)OCH.sub.3                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3 N                                           CH.sub.2 CH.sub.2 CH.sub.3                                                            NO.sub.2   H  CH.sub.3                                                                            OCH.sub.3                                                                               N                                           CH.sub.2 CH.sub.2 CH.sub.3                                                            NO.sub.2   CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               N                                           C.sub.6 H.sub.5                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                            CH.sub.3 CH                                          C.sub.6 H.sub.5                                                                       SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                               CH                                          C.sub.6 H.sub.5                                                                       SO.sub.2 N(CH.sub.3)OCH.sub.3                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                               CH                                          C.sub.6 H.sub.5                                                                       SO.sub.2 N(CH.sub.3)OCH.sub.3                                                             CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                       N                                           C.sub.6 H.sub.5                                                                       NO.sub.2   H  CH.sub.3                                                                            OCH.sub.3                                                                               N                                           C.sub.6 H.sub.5                                                                       NO.sub.2   CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               N                                           C.sub.6 H.sub.5                                                                       NO.sub.2   CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.3 CH                                          H      SO.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                            N(CH.sub.3).sub.2                                                                       N                                           H      SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                               N                                           CH.sub.3                                                                              SO.sub.2 CH.sub.2 CH.sub.3                                                                H  OCH.sub.2 CF.sub.3                                                                  CH.sub.3 CH                                          CH.sub.2 CH.sub.3                                                                     SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                               CH                                          CH(CH.sub.3).sub.2                                                                    SO.sub.2 CH.sub.2 CH.sub.3                                                                H  OCH.sub.3                                                                           OCH.sub.3                                                                               CH                                          C.sub.6 H.sub.5                                                                       SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                          CH.sub.3                                                                            CH.sub.2 CH.sub.2 CH.sub.3                                                              N                                           __________________________________________________________________________

                                      TABLE V                                      __________________________________________________________________________      ##STR23##                                                                     R.sub.10    R.sub.11                                                                           X      Y       Z   m.p. (°C.)                           __________________________________________________________________________     CO.sub.2 CH.sub.3                                                                          H   CH.sub.3                                                                              CH.sub.3                                                                               CH                                              CO.sub.2 CH.sub.3                                                                          H   CH.sub.3                                                                              OCH.sub.3                                                                              CH                                              CO.sub.2 CH.sub.3                                                                          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                              CO.sub.2 CH.sub.3                                                                          H   Cl     OCH.sub.3                                                                              CH                                              CO.sub.2 CH.sub.3                                                                          H   CH.sub.3                                                                              OCH.sub.3                                                                              N                                               CO.sub.2 CH.sub.3                                                                          H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                                               CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                               CH                                              CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                           CH.sub.3                                                                              OCH.sub.3                                                                              CH                                              CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                              CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                           CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                     CH                                              CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                           CH.sub.3                                                                              OCH.sub.3                                                                              N                                               CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              N                                               CO.sub.2 Et H   CH.sub.3                                                                              CH.sub.3                                                                               CH                                              CO.sub.2 Et CH.sub.3                                                                           CH.sub.3                                                                              OCH.sub.3                                                                              CH                                              CO.sub.2 Et CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH  180-183                                     CO.sub.2 Et CH.sub.3                                                                           Br     OCH.sub.3                                                                              CH                                              CO.sub.2 Et CH.sub.3                                                                           CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                     CH                                              CO.sub.2 Et CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                               N                                               CO.sub.2 Et CH.sub.3                                                                           CH.sub.3                                                                              OCH.sub.3                                                                              N   154-157°                             CO.sub.2 Et CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              N   188-188.5°                           CO.sub.2 Et CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                     N                                               CO.sub.2 Et CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                     CH                                              CO.sub.2 Et CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                              SO.sub.2 N(CH.sub.3).sub.2                                                                 H   OCF.sub.2 H                                                                           CH.sub.3                                                                               CH                                              SO.sub.2 N(CH.sub.3).sub.2                                                                 H   CH.sub.3                                                                              OCH.sub.3                                                                              CH                                              SO.sub.2 N(CH.sub.3).sub.2                                                                 H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                              SO.sub.2 N(CH.sub.3).sub.2                                                                 H   CH.sub.3                                                                              CH.sub.3                                                                               N                                               SO.sub.2 N(CH.sub.3).sub.2                                                                 H   CH.sub.3                                                                              OCH.sub.3                                                                              N                                               SO.sub.2 NCH.sub.3 (OCH.sub.3).sub.2                                                       H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                                               SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                               CH                                              SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H   CH.sub.3                                                                              OCH.sub.3                                                                              CH                                              SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                              SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H   CH.sub.3                                                                              CH.sub.3                                                                               N                                               SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H   CH.sub.3                                                                              OCH.sub.3                                                                              N                                               SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      H   OCH.sub.3                                                                             OCH.sub.3                                                                              N                                               SO.sub.2 CH.sub.3                                                                          H   CH.sub.3                                                                              CH.sub.3                                                                               CH                                              SO.sub.2 CH.sub.3                                                                          H   CH.sub.3                                                                              OCH.sub.3                                                                              CH                                              SO.sub.2 CH.sub.3                                                                          H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                              SO.sub.2 CH.sub.3                                                                          H   OCH.sub.3                                                                             CH.sub.3                                                                               N                                               SO.sub.2 CH.sub.3                                                                          H   CH.sub.3                                                                              NHCH.sub.3                                                                             N                                               SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                              N                                               SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              N                                               SO.sub.2 CH.sub.2 CH.sub.3                                                                 H   OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                              SO.sub.2 CH.sub.2 CH.sub. 3                                                                H   CH.sub.3                                                                              OCH.sub.3                                                                              CH                                              SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              CH                                              SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                               N                                               SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                           CH.sub.3                                                                              OCH.sub.3                                                                              N                                               SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                              N                                               SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                      CH                                              SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                           CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                     CH                                              SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                           Cl     OCH.sub.3                                                                              CH                                              NO.sub.2    H   OCH.sub.3                                                                             CH.sub.3                                                                               CH                                              NO.sub.2    H   OCH.sub.3                                                                             CH.sub.3                                                                               N                                               NO.sub.2    H   OCH.sub.3                                                                             OCH.sub.2 CCH                                                                          CH                                              __________________________________________________________________________

                                      TABLE VI                                     __________________________________________________________________________      ##STR24##                                                                     R.sub.12 R.sub.13 R.sub.14                                                                          X     Y        Z  m.p. (°C.)                       __________________________________________________________________________     CO.sub.2 CH.sub.3                                                                       H        H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                         CO.sub.2 CH.sub.3                                                                       H        H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         CO.sub.2 CH.sub.3                                                                       H        H  CH.sub.3                                                                             CH.sub.3 N                                          CO.sub.2 CH.sub.3                                                                       H        H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                          CO.sub.2 CH.sub.3                                                                       H        H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          CO.sub.2 CH.sub.3                                                                       H        H  CH.sub.3                                                                             CH.sub.3 CH                                         CO.sub.2 CH.sub.2 CH.sub.3                                                              H        H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                         CO.sub.2 CH.sub.2 CH.sub.3                                                              H        H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                               CH                                         CO.sub.2 CH.sub.2 CH.sub.3                                                              H        H  CH.sub.3                                                                             CH.sub.3 N                                          CO.sub.2 CH.sub.2 CH.sub.3                                                              H        H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                          CO.sub.2 CH.sub.2 CH.sub.3                                                              H        H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          C(O)N(CH.sub.3).sub.2                                                                   H        H  OCF.sub.2 H                                                                          CH.sub.3 CH                                         C(O)NHC.sub.2 H.sub.5                                                                   H        H  CH.sub.3                                                                             CH.sub.3 CH                                         SO.sub.2 N(CH.sub.3).sub.2                                                              H        H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                         SO.sub.2 N(CH.sub.3).sub.2                                                              H        H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         SO.sub.2 N(CH.sub.3).sub.2                                                              H        H  CH.sub.3                                                                             CH.sub.3 N                                          SO.sub.2 N(CH.sub.3).sub.2                                                              H        H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                          SO.sub.2 N(CH.sub.3).sub.2                                                              H        H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          SO.sub.2 N(CH.sub.3).sub.2                                                              H        H  OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                       N                                          SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           H        H  OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                      CH                                         SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           H        H  Cl    OCH.sub.3                                                                               CH                                         SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           H        H  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                         CO.sub.2 CH.sub.3                                                                       H        CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                         CO.sub.2 CH.sub.3                                                                       H        CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         CO.sub.2 CH.sub.3                                                                       H        CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                          CO.sub.2 CH.sub.3                                                                       H        CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                          CO.sub.2 CH.sub.3                                                                       H        CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          CO.sub.2 CH.sub.3                                                                       H        CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 CH                                         CO.sub.2 CH.sub.2 CH.sub.3                                                              H        CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 CH                                         CO.sub.2 CH.sub.2 CH.sub.3                                                              H        CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                         CO.sub.2 CH.sub.2 CH.sub.3                                                              H        CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         CO.sub.2 CH.sub.2 CH.sub.3                                                              H        CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                          CO.sub.2 CH.sub.2 CH.sub.3                                                              H        CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                          CO.sub.2 CH.sub.2 CH.sub.3                                                              H        CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          SO.sub.2 N(CH.sub.3).sub.2                                                              H        CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                         SO.sub.2 N(CH.sub.3).sub.2                                                              H        CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         SO.sub.2 N(CH.sub.3).sub.2                                                              H        CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                          SO.sub.2 N(CH.sub.3).sub.2                                                              H        CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                          SO.sub.2 N(CH.sub.3).sub.2                                                              H        CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub. 3                                                                              N                                          SO.sub.2 N(CH.sub.3).sub.2                                                              H        CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                       N                                          SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           H        CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.2 CH.sub.2 F                                                                    CH                                         SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           H        CH.sub.3                                                                          Cl    OCH.sub.3                                                                               CH                                         SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           H        CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                         SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                     H        CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         SO.sub.2 CH.sub.3                                                                       H        CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3 CH                                         SO.sub.2 CH.sub.2 CH.sub.3                                                              H        CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          NO.sub.2 H        CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                      CH                                         SO.sub.2 CH.sub.3                                                                       H        H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          SO.sub.2 CH.sub.2 CH.sub.3                                                              H        H  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                         NO.sub.2 H        H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          NO.sub.2 H        H  OCH.sub.3                                                                            Δ  N                                          H        CO.sub.2 CH.sub.3                                                                       H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                         H        CO.sub.2 CH.sub.3                                                                       H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         H        CO.sub.2 CH.sub.3                                                                       H  CH.sub.3                                                                             CH.sub.3 N                                          H        CO.sub.2 CH.sub.3                                                                       H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                          H        CO.sub.2 CH.sub.3                                                                       H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          H        CO.sub.2 CH.sub.3                                                                       H  CH.sub.3                                                                             CH.sub.2 F                                                                              CH                                         H        CO.sub.2 CH.sub.2 CH.sub.3                                                              H  CH.sub.3                                                                             OCH.sub.3                                                                               CH                                         H        CO.sub.2 CH.sub.2 CH.sub.3                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         H        CO.sub.2 CH.sub.2 CH.sub.3                                                              H  CH.sub.3                                                                             CH.sub.3 N                                          H        CO.sub.2 CH.sub.2 CH.sub.3                                                              H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                          H        CO.sub.2 CH.sub.2 CH.sub.3                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          H        CO.sub.2 CH.sub.2 CH.sub.3                                                              H  CH.sub.3                                                                             CH.sub.3 CH                                         H        SO.sub.2 N(CH.sub.3).sub.2                                                              H  CH.sub.3                                                                             OCH.sub.3 CH.sub.2 OCH.sub.3                                                            CH                                         H        SO.sub.2 N(CH.sub.3).sub.2                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         H        SO.sub.2 N(CH.sub.3).sub.2                                                              H  CH.sub.3                                                                             CH.sub.3 N                                          H        SO.sub.2 N(CH.sub.3).sub.2                                                              H  CH.sub.3                                                                             N(CH.sub.3).sub.2                                                                       N                                          H        SO.sub.2 N(CH.sub.3).sub.2                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          H        SO.sub.2 N(CH.sub.3).sub.2                                                              H  OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                       N                                          H        SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           H  OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                      CH                                         H        SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           H  Cl    OCH.sub.3                                                                               CH                                         H        SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           H  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                         H        CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.2 CCH                                                                           CH                                         H        CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         H        CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                          H        CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                          H        CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          H        CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          CH.sub.3                                                                             Δ  CH                                         H        CO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          CH.sub.3                                                                             CF.sub.3 CH                                         H        CO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                         H        CO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         H        CO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                          H        C(O)N(CH.sub.3).sub.2                                                                   CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.2 CH.sub.2 CH.sub.3                                                              N                                          H        C(O)NH.sub.2                                                                            CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          H        SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               CH                                         H        SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         H        SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3 N                                          H        SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                               N                                          H        SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          H        SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                       N                                          H        SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                      CH                                         H        SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           CH.sub.3                                                                          Cl    OCH.sub.3                                                                               CH                                         H        SO.sub.2 N(CH.sub.3)OCH.sub.3                                                           CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                         H        SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                     CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         H        SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3 CH                                         H        SO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          H        NO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                      CH                                         H        SO.sub.2 CH.sub.3                                                                       H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          H        SO.sub.2 CH.sub. 2 CH.sub.3                                                             H  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                         H        NO.sub.2 H  OCH.sub.3                                                                            SCH.sub.3                                                                               N                                          H        NO.sub.2 H  OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                       CH                                         __________________________________________________________________________

                                      TABLE VII                                    __________________________________________________________________________      ##STR25##                                                                     J  R.sub.5 R.sub.19                                                                              R  X     Y        Z  m.p. (°C.)                       __________________________________________________________________________     J-7                                                                               H       CH.sub.3                                                                              H  OCH.sub.3                                                                            CH.sub.3 CH                                         J-7                                                                               H       Cl     H  OCH.sub.3                                                                            CH.sub.3 CH                                         J-7                                                                               H       NO.sub.2                                                                              H  OCH.sub.3                                                                            CH.sub.3 CH                                         J-7                                                                               H       SCH.sub.2 CH.sub.3                                                                    H  OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                       CH                                         J-7                                                                               H       SO.sub.2 CH.sub.3                                                                     H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3 N                                          J-7                                                                               CH.sub.3                                                                               SO.sub.2 CH.sub.2 CH.sub.3                                                            H  CH.sub.3                                                                             CCH      N                                          J-7                                                                               CO.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH 192-194                                 J-7                                                                               CO.sub.2 CH.sub.3                                                                      H      H  CH.sub.3                                                                             OCH.sub.3                                                                               CH 155-162                                 J-7                                                                               CO.sub.2 CH.sub.3                                                                      H      H  CH.sub.3                                                                             CH.sub.3 CH 153- 156                                J-7                                                                               CO.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                            OCH.sub.3                                                                               N  167-169                                 J-7                                                                               CO.sub.2 CH.sub.3                                                                      H      H  CH.sub.3                                                                             OCH.sub.3                                                                               N  166-167                                 J-7                                                                               CO.sub.2 CH.sub.3                                                                      H      H  Cl    OCH.sub.3                                                                               CH 185-186                                 J-7                                                                               CO.sub.2 CH.sub.3                                                                      H      CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               N  165-166                                 J-7                                                                               Cl      H      H  OCH.sub.3                                                                            CH.sub.2 CH.sub.2 CH.sub.3                                                              CH                                         J-7                                                                               Cl      CH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                      CH                                         J-7                                                                               SO.sub.2 N(CH.sub.3).sub.2                                                             H      H  OCH.sub.3                                                                            CF.sub.3 CH                                         J-7                                                                               SO.sub.2 N(CH.sub.3).sub.2                                                             H      H  OCH.sub.3                                                                            SCH.sub.3                                                                               CH                                         J-7                                                                               SO.sub.2 CH.sub.3                                                                      Cl     H  OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                     CH                                         J-7                                                                               SO.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                            OCH.sub.2 CHCH.sub.2                                                                    CH                                         J-7                                                                               SO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCHF.sub.2                                                                           CH.sub.3 CH                                         J-8                                                                               H       --     H  OCH.sub.3                                                                            CH.sub.3 CH                                         J-8                                                                               CH.sub.3                                                                               --     H  OCH.sub.3                                                                            CH.sub.3 N                                          J-8                                                                               CO.sub.2 CH.sub.3                                                                      --     H  OCH.sub.3                                                                            CH.sub.3 CH                                         J-8                                                                               CO.sub.2 CH.sub.3                                                                      --     H  OCH.sub.3                                                                            CH.sub.3 N                                          J-8                                                                               Cl      --     H  OCH.sub.3                                                                            OCH.sub.2 CH.sub.2 F                                                                    CH                                         J-8                                                                               SO.sub.2 N(CH.sub.3).sub.2                                                             --     H  OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                      N                                          J-8                                                                               SO.sub.2 CH.sub.3                                                                      --     H  OCH.sub.3                                                                            CH.sub.3 CH                                         J-8                                                                               NO.sub.2                                                                               --     H  OCH.sub.3                                                                            NHCH.sub.3                                                                              CH                                         J-9                                                                               H       Br     H  OCF.sub.2 H                                                                          CH.sub.3 CH                                         J-9                                                                               H       CH.sub.3                                                                              H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                          J-9                                                                               CH.sub.3                                                                               NO.sub.2                                                                              H  OCH.sub.3                                                                            OCF.sub.2 H                                                                             CH                                         J-9                                                                               Cl      SCH.sub.3                                                                             H  CH.sub.3                                                                             OCH.sub.3                                                                               N                                          J-9                                                                               CO.sub.2 CH.sub.3                                                                      Cl     H  Cl    OCH.sub.3                                                                               CH                                         J-9                                                                               CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          J-9                                                                               CO.sub.2 CH.sub.3                                                                      SO.sub.2 CH.sub.3                                                                     H  Br    OCH.sub.3                                                                               CH                                         J-9                                                                               SO.sub.2 N(CH.sub.3).sub.2                                                             H      H  CH.sub.3                                                                             CH.sub.3 N                                          J-9                                                                               SO.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                       CH                                         J-9                                                                               SO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCH.sub.3                                                                            Δ  N                                          J-10                                                                              H       SO.sub.2 CH.sub.2 CH.sub.3                                                            H  OCH.sub.3                                                                            CH.sub.3 CH                                         J-10                                                                              H       NO.sub.2                                                                              H  OCH.sub.3                                                                            CH.sub.3 N                                          J-10                                                                              CH.sub.3                                                                               Cl     H  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                      CH                                         J-10                                                                              Cl      Cl     H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          J-10                                                                              CO.sub.2 CH.sub.3                                                                      SCH.sub.3                                                                             H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         J-10                                                                              CO.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          J-10                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCH.sub.3                                                                            CH(OEt).sub.2                                                                           CH                                         J-10                                                                              SO.sub.2 N(CH.sub.3)Et                                                                 H      H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          J-10                                                                              SO.sub.2 CH.sub.3                                                                      H      CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         J-10                                                                              SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                              H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          J-11                                                                              Cl      --     H  OCH.sub.3                                                                            OCH.sub.3                                                                               CH                                         J-11                                                                              Br      --     H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          J-11                                                                              CH.sub.3                                                                               --     H  OCH.sub.3                                                                            OCH.sub.2 CCH                                                                           CH                                         J-11                                                                              CO.sub.2 CH.sub.3                                                                      --     H  OCH.sub.3                                                                            CH.sub.3 N                                          J-11                                                                              CO.sub.2 CH.sub.3                                                                      --     H  OCH.sub.3                                                                            CF.sub.3 CH                                         J-11                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                             --     H  OCH.sub.3                                                                            OCH.sub.3                                                                               N                                          J-11                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                             --     H  CH.sub.3                                                                             C CH     CH                                         J-11                                                                              SO.sub.2 CH.sub.3                                                                      --     H  CH.sub.3                                                                             N(CH.sub.3).sub.2                                                                       N                                          J-11                                                                              SO.sub.2 CH.sub.2 CH.sub.3                                                             --     H  CH.sub.3                                                                             CH.sub.2 F                                                                              CH                                         __________________________________________________________________________

                  TABLE VIII                                                       ______________________________________                                          ##STR26##                                                                     J   R.sub.4   R.sub.5                                                                           R.sub.6    R.sub.19                                                                              X.sub.1                                                                               Y.sub.1                              ______________________________________                                         J.sub.2                                                                            H  CH.sub.3  CH.sub.3   --     CH.sub.3                                                                              O                                    J.sub.2                                                                            CH.sub.3 Cl  CH.sub.3   --     OCH.sub.3                                                                             CH.sub.2                             J.sub.2                                                                            H  Br        CH.sub.2 CH.sub.2 CH.sub.3                                                                --     OCH.sub.3                                                                             O                                    J.sub.2                                                                            CH.sub.3 CO.sub.2 CH.sub.3                                                                  CH.sub.2 CH.sub.2 CH.sub.3                                                                --     OCH.sub.3                                                                             O                                    J.sub.2                                                                            CH.sub.3 SO.sub.2 N(CH.sub.3).sub.2                                                         CH.sub.3   --     CH.sub.3                                                                              O                                    J.sub.2                                                                            CH.sub.3 H   SO.sub.2 CH.sub.3                                                                         --     OCH.sub.3                                                                             CH.sub.2                             J.sub.2                                                                            CH.sub.3 SO.sub.2 CH.sub.2 CH.sub.3                                                         CH.sub.3   --     CH.sub.3                                                                              O                                    J.sub.7                                                                            --  CH.sub.3 --         SCH.sub.3                                                                             OCH.sub.3                                                                             O                                    J.sub.7                                                                            --  Cl       --         CH.sub.3                                                                              OCH.sub.3                                                                             CH.sub.2                             J.sub.7                                                                            --  CO.sub.2 CH.sub.3                                                                       --         CH.sub.3                                                                              CH.sub. 3                                                                             O                                    J.sub.7                                                                            --  H        --         SO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             O                                    J.sub.7                                                                            --  SO.sub.2 CH.sub.3                                                                       --         Cl     OCH.sub.3                                                                             O                                    J.sub.7                                                                            --  SO.sub.2 N(CH.sub.3).sub.2                                                              --         H      CH.sub.3                                                                              O                                    J.sub.8                                                                            --  CH.sub.3 --         --     OCH.sub.3                                                                             CH.sub.2                             J.sub.8                                                                            --  Cl       --         --     CH.sub.3                                                                              O                                    J.sub.8                                                                            --  CO.sub.2 CH.sub.3                                                                       --         --     OCH.sub.3                                                                             O                                    J.sub.8                                                                            --  CO.sub.2 CH.sub.2 CH.sub.3                                                              --         --     OCH.sub.2 CH.sub.3                                                                     O                                   J.sub.8                                                                            --  NO.sub.2 --         --     CH.sub.3                                                                              O                                    J.sub.8                                                                            --  SO.sub.2 CH.sub.3                                                                       --         --     OCF.sub.2 H                                                                           CH.sub.2                             J.sub.8                                                                            --  SO.sub.2 CH.sub.3                                                                       --         --     OCH.sub.3                                                                             CH.sub.2                             J.sub.9                                                                            --  Cl       --         CH.sub.3                                                                              OCH.sub.3                                                                             O                                    J.sub.9                                                                            --  CO.sub.2 CH.sub.3                                                                       --         CH.sub.3                                                                              OCH.sub.3                                                                             O                                    J.sub.9                                                                            --  SO.sub.2 CH.sub.2 CH.sub.3                                                              --         CH.sub.3                                                                              CH.sub.3                                                                              O                                    J.sub.10                                                                           --  SO.sub.2 CH.sub.3                                                                       --         CH.sub.3                                                                              CH.sub.3                                                                              O                                    J.sub.10                                                                           --  Cl       --         CH.sub.3                                                                              OCH.sub.3                                                                             CH.sub.2                             J.sub.10                                                                           --  CO.sub.2 CH.sub.3                                                                       --         SCH.sub.3                                                                             OCH.sub.3                                                                             O                                    J.sub.10                                                                           --  SO.sub.2 CH.sub.3                                                                       --         Cl     CH.sub.3                                                                              CH.sub.2                             J.sub.11                                                                           --  Cl       --         --     OCH.sub.3                                                                             O                                    J.sub.11                                                                           --  CO.sub.2 CH.sub.3                                                                       --         --     OCH.sub.3                                                                             O                                    J.sub.11                                                                           --  SO.sub.2 N(CH.sub.3).sub.2                                                              --         --     OCH.sub.3                                                                             CH.sub.2                             J.sub.11                                                                           --  SO.sub.2 CH.sub.3                                                                       --         --     CH.sub.3                                                                              O                                    ______________________________________                                    

                                      TABLE IX                                     __________________________________________________________________________      ##STR27##                                                                     J  R.sub.1  R.sub.2                                                                           R.sub.3                                                                           R.sub.7                                                                           R.sub.8  X.sub.1                                                                              Y.sub.1                                    __________________________________________________________________________     J.sub.1                                                                           CH.sub.3 H  H  -- --       CH.sub.3                                                                             O                                          J.sub.1                                                                           CH.sub.3 CH.sub.3                                                                          CH.sub.3                                                                          -- --       OCH.sub.3                                                                            CH.sub.2                                   J.sub.1                                                                           CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          CH.sub.3                                                                          -- --       CH.sub.3                                                                             CH.sub.2                                   J.sub.1                                                                           CO.sub.2 CH.sub.3                                                                       H  H  -- --       OCH.sub.3                                                                            O                                          J.sub.1                                                                           CO.sub.2 CH.sub.3                                                                       H  H  -- --       OCF.sub.2 H                                                                          CH.sub.2                                   J.sub.1                                                                           CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          H  -- --       OCH.sub.3                                                                            O                                          J.sub.1                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                              H  H  -- --       CH.sub.3                                                                             O                                          J.sub.1                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          H  -- --       CH.sub.3                                                                             O                                          J.sub.1                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                              H  H  -- --       CH.sub.3                                                                             O                                          J.sub.1                                                                           SO.sub.2 N(CH.sub.3 ).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          -- --       OCH.sub.2 CH.sub.3                                                                   CH.sub.2                                   J.sub.1                                                                           SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                     H  H  -- --       OCH.sub.3                                                                            O                                          J.sub.1                                                                           SO.sub.2 CH.sub.3                                                                       H  H  -- --       OCH.sub.3                                                                            CH.sub.2                                   J.sub.1                                                                           SO.sub.2 CH.sub.3                                                                       H  CH.sub.3                                                                          -- --       OCH.sub.3                                                                            O                                          J.sub.1                                                                           SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          CH.sub.3                                                                          -- --       CH.sub.3                                                                             O                                          J.sub.1                                                                           SO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          CH.sub.3                                                                          -- --       CH.sub.3                                                                             CH.sub.2                                   J.sub.3                                                                           --       -- -- H  CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             O                                          J.sub.3                                                                           --       -- -- H  CO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             O                                          J.sub.3                                                                           --       -- -- CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                              OCH.sub.3                                                                            CH.sub.2                                   J.sub.3                                                                           --       -- -- CH.sub.3                                                                          SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           OCH.sub.3                                                                            CH.sub.2                                   J.sub.3                                                                           --       -- -- H  SO.sub.2 CH.sub.3                                                                       OCH.sub.3                                                                            O                                          J.sub.3                                                                           --       -- -- H  SO.sub.2 CH.sub.3                                                                       OCH.sub.3                                                                            CH.sub.2                                   J.sub.3                                                                           --       -- -- CH.sub.3                                                                          SO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             O                                          J.sub.3                                                                           --       -- -- CH.sub.3                                                                          NO.sub.2 CH.sub.3                                                                             O                                          __________________________________________________________________________

                                      TABLE X                                      __________________________________________________________________________      ##STR28##                                                                     J  R.sub.9                                                                               R.sub.10 R.sub.11                                                                          R.sub.12                                                                            R.sub.13                                                                              R.sub.14                                                                          X.sub.1                                                                              Y.sub.1                             __________________________________________________________________________     J.sub.4                                                                           H      CO.sub.2 CH.sub.3                                                                       H  --   --     -- OCH.sub.3                                                                            CH.sub.2                            J.sub.4                                                                           CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                                                             O                                   J.sub.4                                                                           CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                                                             O                                   J.sub.4                                                                           CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                              H  --   --     -- OCH.sub.3                                                                            O                                   J.sub.4                                                                           CH.sub.3                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                            O                                   J.sub.4                                                                           CH.sub.3                                                                              SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           CH.sub.3                                                                          --   --     -- OCH.sub.2 CH.sub.3                                                                   CH.sub.2                            J.sub.4                                                                           CH.sub.3                                                                              SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                                                             O                                   J.sub.4                                                                           CH.sub.3                                                                              SO.sub.2 CH.sub.3                                                                       CH.sub. 3                                                                         --   --     -- OCF.sub.2 H                                                                          O                                   J.sub.4                                                                           CH.sub.2 CH.sub.2 CH.sub.3                                                            CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                            CH.sub.2                            J.sub.4                                                                           CH.sub.3                                                                              NO.sub.2 CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                            O                                   J.sub.4                                                                           CH.sub.3                                                                              SO.sub.2 CH.sub.2 CH.sub.3                                                              H  --   --     -- CH.sub.3                                                                             O                                   J.sub.4                                                                           Ph     CO.sub.2 CH.sub.3                                                                       H  --   --     -- OCH.sub.3                                                                            CH.sub.2                            J.sub.5                                                                           --     CO.sub.2 CH.sub.3                                                                       H  --   --     -- OCH.sub.3                                                                            O                                   J.sub.5                                                                           --     CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                            O                                   J.sub.5                                                                           --     CO.sub.2 H.sub.3                                                                        H  --   --     -- CH.sub.3                                                                             O                                   J.sub.5                                                                           --     SO.sub.2 N(CH.sub.3).sub.2                                                              H  --   --     -- OCH.sub.3                                                                            CH.sub.2                            J.sub.5                                                                           --     SO.sub.2 N(CH.sub.3)Et                                                                  H  --   --     -- OCH.sub.3                                                                            O                                   J.sub.5                                                                           --     SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                                                             O                                   J.sub.5                                                                           --     SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                            O                                   J.sub.5                                                                           --     SO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                            CH.sub.2                            J.sub.5                                                                           --     NO.sub.2 H  --   --     -- OCH.sub.3                                                                            O                                   J.sub.6                                                                           --     --       -- H    CO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                                                             O                                   J.sub.6                                                                           --     --       -- H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2                            J.sub.6                                                                           --     --       -- CH.sub.3                                                                            H      CH.sub.3                                                                          CH.sub.3                                                                             O                                   J.sub.6                                                                           --     --       -- H    SO.sub.2 N(CH.sub.3).sub.2                                                            CH.sub.3                                                                          OCH.sub.3                                                                            O                                   J.sub.6                                                                           --     --       -- NO.sub.2                                                                            H      CH.sub.3                                                                          OCH.sub.3                                                                            O                                   J.sub.6                                                                           --     --       -- H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2                            J.sub.6                                                                           --     --       -- CO.sub.2 CH.sub.3                                                                   H      H  CH.sub.3                                                                             O                                   J.sub.6                                                                           --     --       -- CO.sub.2 CH.sub.3                                                                   H      CH.sub.3                                                                          CH.sub.3                                                                             O                                   J.sub.6                                                                           --     --       -- SO.sub.2 CH.sub.3                                                                   H      CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2                            __________________________________________________________________________

                                      TABLE XI                                     __________________________________________________________________________      ##STR29##                                                                     J  R.sub.1  R.sub.2                                                                           R.sub.3                                                                           R.sub.7                                                                           R.sub.8  X.sub.1                                          __________________________________________________________________________     J.sub.1                                                                           CH.sub.3 H  H  -- --       CH.sub.3                                         J.sub.1                                                                           CH.sub.3 CH.sub.3                                                                          CH.sub.3                                                                          -- --       OCH.sub.3                                        J.sub.1                                                                           CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          CH.sub.3                                                                          -- --       CH.sub.3                                         J.sub.1                                                                           CO.sub.2 CH.sub.3                                                                       H  H  -- --       OCH.sub.3                                        J.sub.1                                                                           CO.sub.2 CH.sub.3                                                                       H  H  -- --       OCF.sub.2 H                                      J.sub.1                                                                           CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          H  -- --       OCH.sub.3                                        J.sub.1                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                              H  H  -- --       CH.sub.3                                         J.sub.1                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          H  -- --       CH.sub.3                                         J.sub.1                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                              H  H  -- --       CH.sub.3                                         J.sub.1                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                              H  CH.sub.3                                                                          -- --       OCH.sub.3                                        J.sub.1                                                                           SO.sub.2 N(CH.sub. 3).sub.2                                                             CH.sub.3                                                                          CH.sub.3                                                                          -- --       OCH.sub.2 CH.sub.3                               J.sub.1                                                                           SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                     H  H  -- --       OCH.sub.3                                        J.sub.1                                                                           SO.sub.2 CH.sub.3                                                                       H  H  -- --       OCH.sub.3                                        J.sub.1                                                                           SO.sub.2 CH.sub.3                                                                       H  CH.sub.3                                                                          -- --       OCH.sub.3                                        J.sub.1                                                                           SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          CH.sub.3                                                                          -- --       CH.sub.3                                         J.sub.1                                                                           SO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          CH.sub.3                                                                          -- --       CH.sub.3                                         J.sub.3                                                                           --       -- -- H  CO.sub.2 CH.sub.3                                                                       CH.sub.3                                         J.sub.3                                                                           --       -- -- H  CO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                         J.sub.3                                                                           --       -- -- H  SO.sub.2 N(CH.sub.3).sub.2                                                              OCH.sub.3                                        J.sub.3                                                                           --       -- -- CH.sub.3                                                                          SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           OCH.sub.3                                        J.sub.3                                                                           --       -- -- H  SO.sub.2 CH.sub.3                                                                       OCH.sub.3                                        J.sub.3                                                                           --       -- -- H  SO.sub.2 CH.sub.3                                                                       OCH.sub.2 CH.sub.3                               J.sub.3                                                                           --       -- -- CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                       CH.sub.3                                         J.sub.3                                                                           --       -- -- CH.sub.3                                                                          NO.sub.2 CH.sub.3                                         __________________________________________________________________________

                  TABLE XII                                                        ______________________________________                                          ##STR30##                                                                     J    R.sub.4                                                                               R.sub.5    R.sub.6  R.sub.19                                                                              X.sub.1                                 ______________________________________                                         J.sub.2                                                                             H      CH.sub.3   CH.sub.3 --     CH.sub.3                                J.sub.2                                                                             CH.sub.3                                                                              Cl         CH.sub.3 --     OCH.sub.3                               J.sub.2                                                                             H      Br         CH.sub.2 CH.sub.2 CH.sub.3                                                              --     OCF.sub.2 H                             J.sub.2                                                                             CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                         CH.sub.3 --     OCH.sub.3                               J.sub.2                                                                             CH.sub.3                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3 --     CH.sub.3                                J.sub.2                                                                             CH.sub.3                                                                              SO.sub.2 CH.sub.3                                                                         SO.sub.2 CH.sub.3                                                                       --     OCH.sub.3                               J.sub.2                                                                             CH.sub.3                                                                              SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3 --     CH.sub.3                                J.sub.7                                                                             --     CH.sub.3   --       SCH.sub.3                                                                             OCH.sub.3                               J.sub.7                                                                             --     Cl         --       CH.sub.3                                                                              OCH.sub.3                               J.sub.7                                                                             --     CO.sub.2 CH.sub.3                                                                         --       CH.sub.3                                                                              CH.sub.3                                J.sub.7                                                                             --     H          --       SO.sub.2 CH.sub.3                                                                     OCH.sub.3                               J.sub.7                                                                             --     SO.sub.2 CH.sub.3                                                                         --       Cl     OCH.sub.3                               J.sub.7                                                                             --     SO.sub.2 N(CH.sub.3).sub.2                                                                --       SCH.sub.3                                                                             CH.sub.3                                J.sub.8                                                                             --     CH.sub.3   --       --     OCH.sub.3                               J.sub.8                                                                             --     Cl         --       --     CH.sub.3                                J.sub.8                                                                             --     CO.sub.2 CH.sub.3                                                                         --       --     OCH.sub.3                               J.sub.8                                                                             --     CO.sub.2 CH.sub.2 CH.sub.3                                                                --       --     OCH.sub.2 CH.sub.3                      J.sub.8                                                                             --     NO.sub.2   --       --     CH.sub.3                                J.sub.8                                                                             --     SO.sub.2 CH.sub.3                                                                         --       --     OCH.sub.3                               J.sub.9                                                                             --     Cl         --       CH.sub.3                                                                              OCH.sub.3                               J.sub.9                                                                             --     CO.sub.2 CH.sub.3                                                                         --       H      OCH.sub.3                               J.sub.9                                                                             --     SO.sub.2 CH.sub.3                                                                         --       CH.sub.3                                                                              CH.sub.3                                J.sub.10                                                                            --     Cl         --       CH.sub.3                                                                              OCH.sub.3                               J.sub.10                                                                            --     CO.sub.2 CH.sub.3                                                                         --       SCH.sub.3                                                                             OCH.sub.3                               J.sub.10                                                                            --     SO.sub.2 CH.sub.3                                                                         --       Cl     CH.sub.3                                J.sub.11                                                                            --     Cl         --       --     OCH.sub.3                               J.sub.11                                                                            --     CO.sub.2 CH.sub.3                                                                         --       --     OCH.sub.3                               J.sub.11                                                                            --     SO.sub.2 N(CH.sub.3).sub.2                                                                --       --     OCH.sub.3                               J.sub.11                                                                            --     SO.sub.2 CH.sub.3                                                                         --       --     CH.sub.3                                ______________________________________                                    

                                      TABLE XIII                                   __________________________________________________________________________      ##STR31##                                                                     J  R.sub.9                                                                               R.sub.10                                                                               R.sub.11                                                                          R.sub.12                                                                            R.sub.13                                                                              R.sub.14                                                                          X.sub.1                                    __________________________________________________________________________     J.sub.4                                                                           H      CO.sub.2 CH.sub.3                                                                      H  --   --     -- OCH.sub.3                                  J.sub.4                                                                           CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          --   --     -- CH.sub.3                                   J.sub.4                                                                           CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                             H  --   --     -- OCH.sub.3                                  J.sub.4                                                                           CH.sub.3                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                          --   --     -- OCH.sub.2 CH.sub.3                         J.sub.4                                                                           CH.sub.3                                                                              SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          --   --     -- CH.sub.3                                   J.sub.4                                                                           CH.sub.3                                                                              SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          --   --     -- OCF.sub.2 H                                J.sub.4                                                                           CH.sub.2 CH.sub.2 CH.sub.2                                                            CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          --   --     -- OCH.sub.3                                  J.sub.4                                                                           CH.sub.3                                                                              NO.sub.2                                                                               CH.sub.3                                                                          --   --     -- OCH.sub.3                                  J.sub.4                                                                           CH.sub. 3                                                                             SO.sub.2 CH.sub.2 CH.sub.3                                                             H  --   --     -- CH.sub.3                                   J.sub.4                                                                           Ph     CO.sub.2 CH.sub.3                                                                      H  --   --     -- OCH.sub.3                                  J.sub.5                                                                           --     CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          --   --     -- OCH.sub.3                                  J.sub.5                                                                           --     CO.sub.2 CH.sub.3                                                                      H  --   --     -- OCH.sub.3                                  J.sub.5                                                                           --     CO.sub.2 H.sub.3                                                                       H  --   --     -- CH.sub.3                                   J.sub.5                                                                           --     SO.sub.2 N(CH.sub.3).sub.2                                                             H  --   --     -- OCH.sub.3                                  J.sub.5                                                                           --     SO.sub.2 N(CH.sub.3)Et                                                                 H  --   --     -- OCH.sub.3                                  J.sub.5                                                                           --     SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          --   --     -- CH.sub.3                                   J.sub.5                                                                           --     SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          --   --     -- OCH.sub.3                                  J.sub.5                                                                           --     SO.sub.2 CH.sub.2 CH.sub.3                                                             CH.sub.3                                                                          --   --     -- OCH.sub.3                                  J.sub.5                                                                           --     NO.sub.2                                                                               H  --   --     -- OCH.sub.3                                  J.sub.6                                                                           --     --      -- H    CO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                   J.sub.6                                                                           --     --      -- H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                          OCH.sub.3                                  J.sub.6                                                                           --     --      -- CH.sub.3                                                                            H      CH.sub.3                                                                          CH.sub.3                                   J.sub.6                                                                           --     --      -- H    SO.sub.2 N(CH.sub.3).sub.2                                                            CH.sub.3                                                                          OCH.sub.3                                  J.sub.6                                                                           --     --      -- NO.sub.2                                                                            H      CH.sub.3                                                                          OCH.sub.3                                  J.sub.6                                                                           --     --      -- H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                          OCH.sub.3                                  J.sub.6                                                                           --     --      -- CO.sub.2 CH.sub.3                                                                   H      CH.sub.3                                                                          CH.sub.3                                   J.sub.6                                                                           --     --      -- CO.sub.2 CH.sub.3                                                                   H      CH.sub.3                                                                          CH.sub.3                                   J.sub.6                                                                           --     --      -- SO.sub.2 CH.sub.3                                                                   H      CH.sub.3                                                                          OCH.sub.3                                  __________________________________________________________________________

                                      TABLE XIV                                    __________________________________________________________________________      ##STR32##                                                                     J R.sub.1   R.sub.2                                                                           R.sub.3                                                                           R.sub.7                                                                           R.sub.8   X.sub.1                                                                              Y.sub.3                                   __________________________________________________________________________     J.sub.1                                                                          CH.sub.3  H  H  -- --        CH.sub.3                                                                             H                                         J.sub.1                                                                          CH.sub.3  CH.sub.3                                                                          CH.sub.3                                                                          -- --        OCH.sub.3                                                                            H                                         J.sub.1                                                                          CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          CH.sub.3                                                                          -- --        CH.sub.3                                                                             H                                         J.sub.1                                                                          CO.sub.2 CH.sub.3                                                                        H  H  -- --        OCH.sub.3                                                                            H                                         J.sub.1                                                                          CO.sub.2 CH.sub.3                                                                        H  H  -- --        OCF.sub.2 H                                                                          CH.sub.3                                  J.sub.1                                                                          CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          H  -- --        OCH.sub.3                                                                            CH.sub.3                                  J.sub.1                                                                          CO.sub.2 CH.sub.2 CH.sub.3                                                               H  H  -- --        CH.sub.3                                                                             CH.sub.3                                  J.sub.1                                                                          CO.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                          H  -- --        CH.sub.3                                                                             H                                         J.sub.1                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                               H  H  -- --        CH.sub.3                                                                             H                                         J.sub.1                                                                          SO.sub.2 N(CH.sub.3 ).sub.2                                                              H  CH.sub.3                                                                          -- --        OCH.sub.3                                                                            H                                         J.sub.1                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                          CH.sub.3                                                                          -- --        OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                  J.sub.1                                                                          SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                      H  H  -- --        OCH.sub.3                                                                            CH.sub.3                                  J.sub.1                                                                          SO.sub.2 CH.sub.3                                                                        H  H  -- --        OCH.sub.3                                                                            CH.sub.3                                  J.sub.1                                                                          SO.sub.2 CH.sub.3                                                                        H  CH.sub.3                                                                          -- --        OCH.sub.3                                                                            H                                         J.sub.1                                                                          SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                          CH.sub.3                                                                          -- --        CH.sub.3                                                                             H                                         J.sub.1                                                                          SO.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                          CH.sub.3                                                                          -- --        CH.sub.3                                                                             H                                         J.sub.3                                                                          --        -- -- H  CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                  J.sub.3                                                                          --        -- -- H  CO.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                  J.sub.3                                                                          --        -- -- CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            CH.sub.3                                  J.sub.3                                                                          --        -- -- CH.sub.3                                                                          SO.sub.2 N(OCH.sub.3)CH.sub.3                                                            OCH.sub.3                                                                            H                                         J.sub.3                                                                          --        -- -- H  SO.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            H                                         J.sub.3                                                                          --        -- -- CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            H                                         J.sub.3                                                                          --        -- -- CH.sub.3                                                                          SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                  J.sub.3                                                                          --        -- -- CH.sub.3                                                                          NO.sub.2  CH.sub.3                                                                             CH.sub.3                                  __________________________________________________________________________

                                      TABLE XV                                     __________________________________________________________________________      ##STR33##                                                                     J  R.sub.4                                                                            R.sub.5 R.sub.6 R.sub.19                                                                             X.sub.1                                                                               Y.sub.3                                    __________________________________________________________________________     J.sub.2                                                                           H   CH.sub.3                                                                               CH.sub.3                                                                               --    CH.sub.3                                                                              H                                          J.sub.2                                                                           CH.sub.3                                                                           Cl      CH.sub.3                                                                               --    OCH.sub.3                                                                             H                                          J.sub.2                                                                           H   Br      CH.sub.2 CH.sub.2 CH.sub.3                                                             --    OCH.sub.3                                                                             H                                          J.sub.2                                                                           CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                               --    OCH.sub.3                                                                             CH.sub.3                                   J.sub.2                                                                           CH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                               --    CH.sub.3                                                                              CH.sub.3                                   J.sub.2                                                                           CH.sub.3                                                                           H       SO.sub.2 CH.sub.3                                                                      --    OCH.sub.3                                                                             CH.sub.3                                   J.sub.2                                                                           CH.sub.3                                                                           SO.sub.2 CH.sub.2 CH.sub.3                                                             CH.sub.3                                                                               --    CH.sub.3                                                                              H                                          J.sub.7                                                                           --  CH.sub.3                                                                               --      SCH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                   J.sub.7                                                                           --  Cl      --      CH.sub.3                                                                             OCH.sub.3                                                                             CH.sub.3                                   J.sub.7                                                                           --  CO.sub.2 CH.sub.3                                                                      --      CH.sub.3                                                                             CH.sub.3                                                                              CH.sub.3                                   J.sub.7                                                                           --  H       --      SO.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                             CH.sub.3                                   J.sub.7                                                                           --  SO.sub.2 CH.sub.3                                                                      --      Cl    OCH.sub.3                                                                             CH.sub.3                                   J.sub.7                                                                           --  SO.sub.2 N(CH.sub.3).sub.2                                                             --      SCH.sub.3                                                                            CH.sub.3                                                                              H                                          J.sub.8                                                                           --  CH.sub.3                                                                               --      --    OCH.sub.3                                                                             H                                          J.sub.8                                                                           --  Cl      --      --    CH.sub.3                                                                              H                                          J.sub.8                                                                           --  CO.sub.2 CH.sub.3                                                                      --      --    OCH.sub.3                                                                             H                                          J.sub.8                                                                           --  CO.sub.2 CH.sub.2 CH.sub.3                                                             --      --    OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                   J.sub.8                                                                           --  NO.sub.2                                                                               --      --    CH.sub.3                                                                              CH.sub.3                                   J.sub.8                                                                           --  SO.sub.2 CH.sub.3                                                                      --      --    OCH.sub.3                                                                             CH.sub.3                                   J.sub.9                                                                           --  Cl      --      CH.sub.3                                                                             OCH.sub.3                                                                             H                                          J.sub.9                                                                           --  CO.sub.2 CH.sub.3                                                                      --      CH.sub.3                                                                             OCH.sub.3                                                                             H                                          J.sub.9                                                                           --  SO.sub.2 CH.sub.3                                                                      --      CH.sub.3                                                                             CH.sub.3                                                                              CH.sub.3                                   J.sub.10                                                                          --  Cl      --      CH.sub.3                                                                             OCH.sub.3                                                                             H                                          J.sub.10                                                                          --  CO.sub.2 CH.sub.3                                                                      --      SCH.sub.3                                                                            OCH.sub.3                                                                             CH.sub.3                                   J.sub. 10                                                                         --  SO.sub.2 CH.sub.3                                                                      --      Cl    CH.sub.3                                                                              CH.sub.3                                   J.sub.11                                                                          --  Cl      --      --    OCF.sub.2 H                                                                           CH.sub.3                                   J.sub.11                                                                          --  CO.sub.2 CH.sub.3                                                                      --      --    OCH.sub.3                                                                             H                                          J.sub.11                                                                          --  SO.sub.2 N(CH.sub.3).sub.2                                                             --      --    OCH.sub.3                                                                             H                                          J.sub.11                                                                          --  SO.sub.2 CH.sub.3                                                                      --      --    CH.sub.3                                                                              H                                          __________________________________________________________________________

                                      TABLE XVI                                    __________________________________________________________________________      ##STR34##                                                                     J R.sub.9                                                                               R.sub.10 R.sub.11                                                                          R.sub.12                                                                            R.sub.13                                                                              R.sub.14                                                                          X.sub.1                                                                              Y.sub.3                              __________________________________________________________________________     J.sub.4                                                                          H      CO.sub.2 CH.sub.3                                                                       H  --   --     -- OCH.sub.3                                                                            H                                    J.sub.4                                                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                                                             H                                    J.sub.4                                                                          CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                              H  --   --     -- OCH.sub.3                                                                            H                                    J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                            H                                    J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           CH.sub.3                                                                          --   --     -- OCH.sub.2 CH.sub.3                                                                   CH.sub.3                             J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- OCF.sub.2 H                                                                          CH.sub.3                             J.sub.4                                                                          CH.sub.2 CH.sub.2 CH.sub.3                                                            CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                            CH.sub.3                             J.sub.4                                                                          CH.sub.3                                                                              NO.sub. 2                                                                               CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                            CH.sub.3                             J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 CH.sub.2 CH.sub.3                                                              H  --   --     -- CH.sub.3                                                                             CH.sub.3                             J.sub.4                                                                          Ph     CO.sub.2 CH.sub.3                                                                       H  --   --     -- OCH.sub.3                                                                            CH.sub.3                             J.sub.5                                                                          --     CO.sub.2 CH.sub.3                                                                       H  --   --     -- OCH.sub.2 CH.sub.3                                                                   H                                    J.sub.5                                                                          --     CO.sub.2 CH.sub.3                                                                       H  --   --     -- OCH.sub.3                                                                            H                                    J.sub.5                                                                          --     CO.sub.2 CH.sub.3                                                                       H  --   --     -- CH.sub.3                                                                             H                                    J.sub.5                                                                          --     SO.sub.2 N(CH.sub.3).sub.2                                                              H  --   --     -- OCH.sub.3                                                                            H                                    J.sub.5                                                                          --     SO.sub.2 N(CH.sub.3)Et                                                                  H  --   --     -- OCH.sub.3                                                                            H                                    J.sub.5                                                                          --     SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                                                             H                                    J.sub.5                                                                          --     SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                            H                                    J.sub.5                                                                          --     SO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                            CH.sub.3                             J.sub.5                                                                          --     NO.sub.2 H  --   --     -- OCH.sub.3                                                                            CH.sub.3                             J.sub.6                                                                          --     --       -- H    CO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                                                             CH.sub.3                             J.sub.6                                                                          --     --       -- H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                             J.sub.6                                                                          --     --       -- CH.sub.3                                                                            H      CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                             J.sub.6                                                                          --     --       -- H    SO.sub.2 N(CH.sub.3).sub.2                                                            CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.3                             J.sub.6                                                                          --     --       -- NO.sub.2                                                                            H      CH.sub.3                                                                          OCH.sub.3                                                                            H                                    J.sub.6                                                                          --     --       -- H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                          OCH.sub.3                                                                            H                                    J.sub.6                                                                          --     --       -- CO.sub.2 CH.sub.3                                                                   H      H  CH.sub.3                                                                             H                                    J.sub.6                                                                          --     --       -- CO.sub.2 CH.sub.3                                                                   H      CH.sub.3                                                                          CH.sub.3                                                                             H                                    J.sub.6                                                                          --     --       -- SO.sub.2 CH.sub.3                                                                   CH.sub.3                                                                              CH.sub.3                                                                          OCH.sub.3                                                                            H                                    __________________________________________________________________________

                                      TABLE XVII                                   __________________________________________________________________________      ##STR35##                                                                     J R.sub.4                                                                           R.sub.5 R.sub.6 R.sub.19                                                                             X.sub.2                                                                              Y.sub.2                                       __________________________________________________________________________     J.sub.2                                                                          H  CH.sub.3                                                                               CH.sub.3                                                                               --    CH.sub.3                                                                             OCH.sub.3                                     J.sub.2                                                                          CH.sub.3                                                                          Cl      CH.sub.3                                                                               --    CH.sub.3                                                                             OCH.sub.3                                     J.sub.2                                                                          H  Br      CH.sub.2 CH.sub.2 CH.sub.3                                                             --    CH.sub.3                                                                             OCH.sub.3                                     J.sub.2                                                                          CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                               --    CH.sub.3                                                                             OCH.sub.3                                     J.sub.2                                                                          CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                               --    CH.sub.3                                                                             OCH.sub.3                                     J.sub.2                                                                          CH.sub.3                                                                          H       SO.sub.2 CH.sub.3                                                                      --    CH.sub.3                                                                             CH.sub.3                                      J.sub.2                                                                          CH.sub.3                                                                          SO.sub.2 CH.sub.2 CH.sub.3                                                             CH.sub.3                                                                               --    C.sub.2 H.sub.5                                                                      OCH.sub.2 CH.sub.3                            J.sub.7                                                                          -- CH.sub.3                                                                               --      SCH.sub.3                                                                            CH.sub.2 CF.sub.3                                                                    OCH.sub.3                                     J.sub.7                                                                          -- Cl      --      CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                     J.sub.7                                                                          -- CO.sub.2 CH.sub.3                                                                      --      CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub. 3                                    J.sub.7                                                                          -- H       --      SO.sub.2 CH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                     J.sub.7                                                                          -- SO.sub.2 CH.sub.3                                                                      --      Cl    CH.sub.3                                                                             SCH.sub.3                                     J.sub.7                                                                          -- SO.sub.2 N(CH.sub.3).sub.2                                                             --      SCH.sub.3                                                                            C.sub.2 H.sub.5                                                                      OCH.sub.3                                     J.sub.8                                                                          -- CH.sub.3                                                                               --      --    CH.sub.2 CF.sub.3                                                                    OCH.sub.3                                     J.sub.8                                                                          -- Cl      --      --    CH.sub.3                                                                             OCH.sub.3                                     J.sub.8                                                                          -- CO.sub.2 CH.sub.3                                                                      --      --    CH.sub.3                                                                             SCF.sub.2 H                                   J.sub.8                                                                          -- CO.sub.2 CH.sub.2 CH.sub.3                                                             --      --    CH.sub.3                                                                             OCH.sub.3                                     J.sub.8                                                                          -- NO.sub.2                                                                               --      --    CH.sub.3                                                                             OCH.sub.3                                     J.sub.8                                                                          -- SO.sub.2 CH.sub.3                                                                      --      --    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                     J.sub.9                                                                          -- Cl      --      CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                     J.sub.9                                                                          -- CO.sub.2 CH.sub.3                                                                      --      SO.sub.2 CH.sub.3                                                                    CH.sub.3                                                                             CH.sub.3                                      J.sub.9                                                                          -- SO.sub.2 CH.sub.3                                                                      --      CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                     J.sub.10                                                                         -- Cl      --      CH.sub.3                                                                             CH.sub.3                                                                             SCH.sub.2 CH.sub.3                            J.sub.10                                                                         -- CO.sub.2 CH.sub.3                                                                      --      SCH.sub.3                                                                            C.sub.2 H.sub.5                                                                      OCH.sub.3                                     J.sub.10                                                                         -- SO.sub.2 CH.sub.3                                                                      --      Cl    CH.sub.2 CF.sub.3                                                                    OCH.sub.3                                     J.sub.11                                                                         -- Cl      --      --    CH.sub.3                                                                             OCH.sub.3                                     J.sub.11                                                                         -- CO.sub.2 CH.sub.3                                                                      --      --    CH.sub.3                                                                             SC.sub.2 H.sub.5                              J.sub.11                                                                         -- SO.sub.2 N(CH.sub.3).sub.2                                                             --      --    CH.sub.3                                                                             OCH.sub.3                                     J.sub.11                                                                         -- SO.sub.2 CH.sub.3                                                                      --      --    CH.sub.3                                                                             OCH.sub.3                                     __________________________________________________________________________

                                      TABLE XVIII                                  __________________________________________________________________________      ##STR36##                                                                     J R.sub.1  R.sub.2                                                                           R.sub.3                                                                           R.sub.7                                                                           R.sub.8  X.sub.2                                                                             Y.sub.2                                      __________________________________________________________________________     J.sub.1                                                                          CH.sub.3 H  H  -- --       CH.sub.3                                                                            OCH.sub.3                                    J.sub.1                                                                          CH.sub.3 CH.sub.3                                                                          CH.sub.3                                                                          -- --       CH.sub.3                                                                            OCH.sub.3                                    J.sub.1                                                                          CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          CH.sub.3                                                                          -- --       CH.sub.3                                                                            OCH.sub.3                                    J.sub.1                                                                          CO.sub.2 CH.sub.3                                                                       H  H  -- --       CH.sub.3                                                                            OCH.sub.3                                    J.sub.1                                                                          CO.sub.2 CH.sub.3                                                                       H  H  -- --       CH.sub.3                                                                            OCH.sub.3                                    J.sub.1                                                                          CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          H  -- --       C.sub.2 H.sub.5                                                                     OCH.sub.3                                    J.sub.1                                                                          CO.sub.2 CH.sub.2 CH.sub.3                                                              H  H  -- --       CH.sub.2 CF.sub.3                                                                   OCH.sub.3                                    J.sub.1                                                                          CO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          H  -- --       CH.sub.3                                                                            OCH.sub.3                                    J.sub.1                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                              H  H  -- --       CH.sub. 3                                                                           CH.sub.3                                     J.sub.1                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                              H  CH.sub.3                                                                          -- --       CH.sub.3                                                                            OEt                                          J.sub.1                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                          CH.sub.3                                                                          -- --       CH.sub.3                                                                            OCH.sub.3                                    J.sub.1                                                                          SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                     H  H  -- --       CH.sub.3                                                                            OCH.sub.3                                    J.sub.1                                                                          SO.sub.2 CH.sub.3                                                                       H  H  -- --       CH.sub.3                                                                            OCH.sub.3                                    J.sub.1                                                                          SO.sub.2 CH.sub.3                                                                       H  CH.sub.3                                                                          -- --       CH.sub.3                                                                            SCH.sub.3                                    J.sub.1                                                                          SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          CH.sub.3                                                                          -- --       CH.sub.3                                                                            CH.sub.2 CH.sub.3                            J.sub.1                                                                          SO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          CH.sub.3                                                                          -- --       C.sub.2 H.sub.5                                                                     OCH.sub.3                                    J.sub.3                                                                          --       -- -- H  CO.sub.2 CH.sub.3                                                                       CH.sub.2 CF.sub.3                                                                   OCH.sub.3                                    J.sub.3                                                                          --       -- -- H  CO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                            OCH.sub.3                                    J.sub.3                                                                          --       -- -- CH.sub.3                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                            SCF.sub.2 H                                  J.sub.3                                                                          --       -- -- CH.sub.3                                                                          SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           CH.sub.3                                                                            OCH.sub.3                                    J.sub.3                                                                          --       -- -- H  SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            OCH.sub.3                                    J.sub.3                                                                          --       -- -- H  SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            OCH.sub.3                                    J.sub.3                                                                          --       -- -- CH.sub.3                                                                          SO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                            SCH.sub.2 CH.sub.3                           J.sub.3                                                                          --       -- -- CH.sub.3                                                                          NO.sub.2 CH.sub.3                                                                            OCH.sub.3                                    __________________________________________________________________________

                                      TABLE XIX                                    __________________________________________________________________________      ##STR37##                                                                     J R.sub.9                                                                               R.sub.10 R.sub.11                                                                          R.sub.12                                                                            R.sub.13                                                                              R.sub.14                                                                          X.sub.2                                                                             Y.sub.2                               __________________________________________________________________________     J.sub.4                                                                          H      CO.sub.2 CH.sub.3                                                                       H  --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.4                                                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.4                                                                          CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                              H  --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                          --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           CH.sub.3                                                                          --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- C.sub.2 H.sub.5                                                                     OCH.sub.3                             J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.4                                                                          CH.sub.2 CH.sub.2 CH.sub.3                                                            CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                                                            CH.sub.3                              J.sub.4                                                                          CH.sub.3                                                                              NO.sub.2 CH.sub.3                                                                          --   --     -- OCH.sub.3                                                                           OCH.sub.2 CH.sub.3                    J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 CH.sub.2 CH.sub.3                                                              H  --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.4                                                                          Ph     CO.sub.2 CH.sub.3                                                                       H  --   --     -- CH.sub.2 CF.sub.3                                                                   CH.sub.3                              J.sub.5                                                                          --     CO.sub.2 CH.sub.3                                                                       H  --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.5                                                                          --     CO.sub.2 CH.sub.3                                                                       H  --   --     -- CH.sub.3                                                                            CH.sub.2 CH.sub.3                     J.sub.5                                                                          --     CO.sub.2 CH.sub.3                                                                       H  --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.5                                                                          --     SO.sub.2 N(CH.sub.3).sub.2                                                              H  --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.5                                                                          --     SO.sub.2 N(CH.sub.3)Et                                                                  H  --   --     -- CH.sub.3                                                                            SCHF.sub.2                            J.sub.5                                                                          --     SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                                                            OCH.sub. 3                            J.sub.5                                                                          --     SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.2 CH.sub.3                                                                   OCH.sub.3                             J.sub.5                                                                          --     SO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.5                                                                          --     NO.sub.2 H  --   --     -- CH.sub.3                                                                            OCH.sub.3                             J.sub.6                                                                          --     --       -- H    CO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                                                            SCH.sub.2 CH.sub.3                    J.sub.6                                                                          --     --       -- H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                             J.sub.6                                                                          --     --       -- CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                             J.sub.6                                                                          --     --       -- H    SO.sub.2 N(CH.sub.3).sub.2                                                            CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                             J.sub.6                                                                          --     --       -- CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                            CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                             J.sub.6                                                                          --     --       -- H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                          CH.sub.2 CF.sub.3                                                                   OCH.sub.3                             J.sub.6                                                                          --     --       -- CO.sub.2 CH.sub.3                                                                   H      H  CH.sub.3                                                                            OCH.sub. 3                            J.sub.6                                                                          --     --       -- CO.sub.2 CH.sub.3                                                                   H      CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                             J.sub.6                                                                          --     --       -- SO.sub.2 CH.sub.3                                                                   CH.sub.3                                                                              CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                             __________________________________________________________________________

                                      TABLE XX                                     __________________________________________________________________________      ##STR38##                                                                     J R.sub.9                                                                               R.sub.10 R.sub.11                                                                          R.sub.12                                                                            R.sub.13                                                                              R.sub.14                                                                          X.sub.3                                    __________________________________________________________________________     J.sub.4                                                                          H      CO.sub.2 CH.sub.3                                                                       H  --   --     -- CH.sub.3                                   J.sub.4                                                                          CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- OCH.sub.3                                  J.sub.4                                                                          CH.sub.3                                                                              CO.sub.2 CH.sub.2 CH.sub.3                                                              H  --   --     -- CH.sub.3                                   J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                          --   --     -- OCH.sub.3                                  J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           CH.sub.3                                                                          --   --     -- CH.sub.3                                   J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- OCH.sub.3                                  J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                   J.sub.4                                                                          CH.sub.2 CH.sub.2 CH.sub.3                                                            CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- OCH.sub.3                                  J.sub.4                                                                          CH.sub.3                                                                              NO.sub.2 CH.sub.3                                                                          --   --     -- CH.sub.3                                   J.sub.4                                                                          CH.sub.3                                                                              SO.sub.2 CH.sub.2 CH.sub.3                                                              H  --   --     -- OCH.sub.3                                  J.sub.4                                                                          Ph     CO.sub.2 CH.sub.3                                                                       H  --   --     -- CH.sub.3                                   J.sub.5                                                                          --     CO.sub.2 CH.sub.3                                                                       H  --   --     -- OCH.sub.3                                  J.sub.5                                                                          --     CO.sub.2 CH.sub.3                                                                       H  --   --     -- CH.sub.3                                   J.sub.5                                                                          --     CO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- OCH.sub.3                                  J.sub.5                                                                          --     SO.sub.2 N(CH.sub.3).sub.2                                                              H  --   --     -- CH.sub.3                                   J.sub.5                                                                          --     SO.sub.2 N(CH.sub.3)Et                                                                  H  --   --     -- OCH.sub.3                                  J.sub.5                                                                          --     SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- CH.sub.3                                   J.sub.5                                                                          --     SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                          --   --     -- OCH.sub.3                                  J.sub.5                                                                          --     SO.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                          --   --     -- CH.sub.3                                   J.sub.5                                                                          --     NO.sub.2 H  --   --     -- OCH.sub.3                                  J.sub.6                                                                          --     --       -- H    CO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                   J.sub.6                                                                          --     --       -- H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                          OCH.sub.3                                  J.sub.6                                                                          --     --       -- CH.sub.3                                                                            H      CH.sub.3                                                                          CH.sub.3                                   J.sub.6                                                                          --     --       -- H    SO.sub.2 N(CH.sub.3).sub.2                                                            CH.sub.3                                                                          OCH.sub.3                                  J.sub.6                                                                          --     --       -- NO.sub.2                                                                            H      CH.sub.3                                                                          CH.sub.3                                   J.sub.6                                                                          --     --       -- H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                          OCH.sub.3                                  J.sub.6                                                                          --     --       -- CO.sub.2 CH.sub.3                                                                   H      H  CH.sub.3                                   J.sub.6                                                                          --     --       -- CO.sub.2 CH.sub.3                                                                   H      CH.sub.3                                                                          OCH.sub.3                                  J.sub.6                                                                          --     --       -- SO.sub.2 CH.sub.3                                                                   CH.sub.3                                                                              CH.sub.3                                                                          CH.sub.3                                   __________________________________________________________________________

                  TABLE XXI                                                        ______________________________________                                          ##STR39##                                                                     JR.sub.1    R.sub.2 R.sub.3                                                                         R.sub.7                                                                               R.sub.8    X.sub.3                                 ______________________________________                                         J.sub.1 CH.sub.3                                                                           HH       --     --         CH.sub.3                                J.sub.1 CH.sub.3                                                                           CH.sub.3 CH.sub.3                                                                       --     --         OCH.sub.3                               J.sub.1 CO.sub.2 CH.sub.3                                                                  CH.sub.3 CH.sub.3                                                                       --     --         CH.sub.3                                J.sub.1 CO.sub.2 CH.sub.3                                                                  HH       --     --         OCH.sub.3                               J.sub.1 CO.sub.2 CH.sub.3                                                                  HH       --     --         CH.sub.3                                J.sub.1 CO.sub.2 CH.sub.3                                                                  CH.sub.3 H                                                                              --     --         OCH.sub.3                               J.sub.1 CO.sub.2 CH.sub.2 CH.sub.3                                                         HH       --     --         CH.sub.3                                J.sub.1 CO.sub.2 CH.sub.2 CH.sub.3                                                         CH.sub.3 H                                                                              --     --         CH.sub.3                                J.sub.1 SO.sub.2 N(CH.sub.3).sub.2                                                         HH       --     --         OCH.sub.3                               J.sub.1 SO.sub.2 N(CH.sub.3).sub.2                                                         HCH.sub.3                                                                               --     --         CH.sub.3                                J.sub.1 SO.sub.2 N(CH.sub.3).sub.2                                                         CH.sub.3 CH.sub.3                                                                       --     --         OCH.sub.3                               J.sub.1 SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                HH       --     --         CH.sub.3                                J.sub.1 SO.sub.2 CH.sub.3                                                                  HH       --     --         OCH.sub.3                               J.sub.1 SO.sub.2 CH.sub.3                                                                  HCH.sub.3                                                                               --     --         CH.sub.3                                J.sub.1 SO.sub.2 CH.sub.3                                                                  CH.sub.3 CH.sub.3                                                                       --     --         CH.sub.3                                J.sub.1 SO.sub.2 CH.sub.2 CH.sub.3                                                         CH.sub.3 CH.sub.3                                                                       --     --         OCH.sub.3                               J.sub.3 --  ----     H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                J.sub.3 --  ----     H      CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                               J.sub.3 --  ----     CH.sub.3                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                J.sub.3 --  ----     CH.sub.3                                                                              SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             OCH.sub.3                               J.sub.3 --  ----     H      SO.sub.2 CH.sub.3                                                                         CH.sub.3                                J.sub.3 --  ----     H      SO.sub.2 CH.sub.3                                                                         OCH.sub.3                               J.sub.3 --  ----     CH.sub.3                                                                              SO.sub.2 CH.sub.3                                                                         CH.sub.3                                J.sub.3 --  ----     CH.sub.3                                                                              NO.sub.2   OCH.sub.3                               ______________________________________                                    

                  TABLE XXII                                                       ______________________________________                                          ##STR40##                                                                     J    R.sub.4                                                                               R.sub.5     R.sub.6  R.sub.19                                                                               X.sub.3                               ______________________________________                                         J.sub.2                                                                             H      CH.sub.3    CH.sub.3 --      CH.sub.3                              J.sub.2                                                                             CH.sub.3                                                                              Cl          CH.sub.3 --      OCH.sub.3                             J.sub.2                                                                             H      Br          CH.sub.2 CH.sub.2 CH.sub.3                                                              --      CH.sub.3                              J.sub.2                                                                             CH.sub.3                                                                              CO.sub.2 CH.sub.3                                                                          CH.sub.3 --      OCH.sub.3                             J.sub.2                                                                             CH.sub.3                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3 --      CH.sub.3                              J.sub.2                                                                             CH.sub.3                                                                              H           SO.sub.2 CH.sub.3                                                                       --      OCH.sub.3                             J.sub.2                                                                             CH.sub.3                                                                              SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3 --      CH.sub.3                              J.sub.7                                                                             --     CH.sub.3    --       SCH.sub.3                                                                              OCH.sub.3                             J.sub.7                                                                             --     Cl          --       CH.sub.3                                                                               CH.sub.3                              J.sub.7                                                                             --     CO.sub.2 CH.sub.3                                                                          --       CH.sub.3                                                                               OCH.sub.3                             J.sub.7                                                                             --     H           --       SO.sub.2 CH.sub.3                                                                      CH.sub.3                              J.sub.7                                                                             --     SO.sub.2 CH.sub.3                                                                          --       Cl      OCH.sub.3                             J.sub.7                                                                             --     SO.sub.2 N(CH.sub.3).sub.2                                                                 --       SCH.sub.3                                                                              CH.sub.3                              J.sub.8                                                                             --     CH.sub.3    --       --      OCH.sub.3                             J.sub.8                                                                             --     Cl          --       --      CH.sub.3                              J.sub.8                                                                             --     CO.sub.2 CH.sub.3                                                                          --       --      OCH.sub.3                             J.sub.8                                                                             --     CO.sub.2 CH.sub.2 CH.sub.3                                                                 --       --      CH.sub.3                              J.sub.8                                                                             --     NO.sub.2    --       --      OCH.sub.3                             J.sub.8                                                                             --     SO.sub.2 CH.sub.3                                                                          --       --      CH.sub.3                              J.sub.9                                                                             --     Cl          --       CH.sub.3                                                                               OCH.sub.3                             J.sub.9                                                                             --     CO.sub.2 CH.sub.3                                                                          --       CH.sub.3                                                                               CH.sub.3                              J.sub.9                                                                             --     SO.sub.2 CH.sub.3                                                                          --       CH.sub.3                                                                               OCH.sub.3                             J.sub.10                                                                            --     Cl          --       CH.sub.3                                                                               CH.sub.3                              J.sub.10                                                                            --     CO.sub.2 CH.sub.3                                                                          --       SCH.sub.3                                                                              OCH.sub.3                             J.sub.10                                                                            --     SO.sub.2 CH.sub.3                                                                          --       Cl      CH.sub.3                              J.sub.11                                                                            --     Cl          --       --      OCH.sub.3                             J.sub.11                                                                            --     CO.sub.2 CH.sub.3                                                                          --       --      CH.sub.3                              J.sub.11                                                                            --     SO.sub. 2 N(CH.sub.3).sub.2                                                                --       --      OCH.sub.3                             J.sub.11                                                                            --     SO.sub.2 CH.sub.3                                                                          --       --      CH.sub.3                              ______________________________________                                    

Formulations

Useful formulation of the compounds of Formula I can be prepared in conventional ways. They include wettable powers, dusts, suspensions, granules, pellets, solutions, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few pints to several hundred gallons per acre. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 5% to 99% solid or liquid diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:

                  TABLE XXIII                                                      ______________________________________                                         Percent by Weight                                                                          Active                                                                         Ingredient                                                                             Diluent(s)                                                                               Surfactant(s)                                    ______________________________________                                         Wettable Powders                                                                             20-90      0-74     1-10                                         Oil Suspensions,                                                                              5-50     40-95     0-15                                         Emulsions, Solutions,                                                          (including Emulsifiable                                                        Concentrates)                                                                  Aqueous Suspension                                                                           10-50     40-84     1-20                                         Dusts          1-25     70-99     0-5                                          Granules and Pellets                                                                          1-95      5-99     0-15                                         High Strength 90-99      0-10     0-2                                          Compositions                                                                   ______________________________________                                    

Lower or higher levels of active ingredients can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd. Edn., Dorland Books, Caldwell, N.J. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide", 2nd. Ed., Interscience, New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. "McCutcheon's Detergents and Emulsifiers Annual", Allured Publ. Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publ. Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foam, corrosion, microbiological growth, etc. Preferably, ingredients should be approved by the U.S. Environmental Protection Agency for the use intended.

The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 4th. Edn., McGraw-Hill, N.Y., 1963, pp. 8-59ff.

For further information regarding the art of formulation, see for example:

H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, Line 16 through Col. 7, Line 19 and Examples 10 through 41.

R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, Line 43 through Col. 7, Line 62 and Ex. 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167, 169-182.

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3, Line 66 through Col. 5, Line 17 and Examples 1-4.

G. C. Klingman, "Weed Control as a Science", John Wiley & Sons, Inc., New York, 1961 pp. 81-96.

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Edn., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.

J. B. Buchanan, U.S. Pat. No. 3,576,834, Apr. 27, 1971, Col. 5, Line 36 through Col. 7, Line 70 and Ex. 1-4, 17, 106, 123-140.

R. R. Shaffer, U.S. Pat. No. 3,560,616 Feb. 2, 1971, Col. 3, Line 48 through Col. 7, Line 26 and Examples 3-9, 11-18.

E. Somers, "Formulation", Chapter 6 in Torgeson, "Fungicides", Vol. I, Academic Press, New York, 1967.

In the following examples, all parts are by weight unless otherwise indicated.

EXAMPLE 5 Wettable Powder

5-[[(4,6-dimethoxyprimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,3-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester: 80%

sodium alkylnaphthalenesulfonate: 2%

sodium ligninsulfonate: 2%

synthetic amorphous silica: 3%

kaolinite: 13%

The ingredients are thoroughly blended, passed through a mill, such as an air mill or hammer mill, to produce an average particle size under 25 microns, reblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) before packaging.

EXAMPLE 6 Wettable Powder

3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,5-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester: 20%

dioctyl sodium sulfosuccinate: 1.5%

sodium ligninsulfonate: 3%

low viscosity methyl cellulose: 1.5%

attapulgite: 74%

The ingredients are thoroughly blended, passed through an air or hammer mill to produce an average particle size under 25 microns, reblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) before packaging.

EXAMPLE 7 High Strength Concentrate

3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,5-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester: 98.5%

silica aerogel: 0.5%

synthetic amorphous fine silica: 1.0%

The ingredients are blended and ground in a hammer mill to produce a high strength concentrate essentially all passing a U.S.S. No. 50 sieve (0.3 mm openings). This material may then be formulated in a variety of ways.

EXAMPLE 8 Dust

wettable powder of Example 6: 5%

pyrophyllite (powder): 95%

The wettable powder and the pyrophyllite diluent are thoroughly blended and then packaged. The product is suitable for use as a dust.

EXAMPLE 9 Dust

5-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,3-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester: 25%

attapulgite: 25%

talc: 50%

The active ingredient is blended with attapulgite and then passed through a hammer mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered talc until homogeneous.

EXAMPLE 10 Aqueous Suspension

5-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,3-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester: 25%

hydrated attapulgite: 3%

crude calcium ligninsulfonate: 10%

water: 62%

The ingredients are ground together in a ball, sand or roller mill until the solid particles have been reduced to diameters under 10 microns.

EXAMPLE 11 Aqueous Suspension

3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,5-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester: 50.0%

dodecylphenol polyethylene glycol ether: 0.5%

crude calcium ligninsulfonate: 5.0%

xanthan gum thickener: 0.2%

paraformaldehyde: 0.2%

water: 44.1%

The ingredients are ground together in a sand, ball or roller mill to produce particles essentially all under five microns in size.

EXAMPLE 12 Oil Suspension

5-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,3-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester: 50%

blend of polyalcohol carboxylic esters and oil soluble petroleum sulfonates: 6%

xylene: 44%

The ingredients are combined and ground together in a sand, ball or roller mill to produce particles essentially all below 3 microns. The product can be used directly, extended with oils, or emulsified in water.

EXAMPLE 13 Oil suspension

3-[[(4,6-dimethoxypryimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,5-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester: 10%

polyoxyethylene sorbitol hexaoleate: 5%

highly aliphatic hydrocarbon oil: 85%

The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water.

EXAMPLE 14 Granule

wettable powder of Example 6: 5%

attapulgite granules (U.S.S. #20-40; 0.84-0.42 mm): 95%

A slurry of wettable powder in water is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged.

EXAMPLE 15 Granule

wettable powder of Example 5: 94%

gypsum: 6%

The ingredients are blended in a rotating or fluid bed mixer and sprayed with water to accomplish granulation. When most of the material has reached the desired range of 2.0 to 0.25 mm. (U.S.S. #10 to 60 sieve), the granules are removed, dried, and screened. Oversize material is crushed to produce additional material in the desired range. These granules contain 75% active ingredient.

EXAMPLE 16 Extruded Pellet

3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,5-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester: 25%

anhydrous sodium sulfate: 10%

crude calcium ligninsulfonate: 5%

sodium alkylnaphthalenesulfonate: 1%

calcium/magnesium bentonite: 59%

The ingredients are blended, hammer milled and then moistened with about 12% water. The mixture is extruded as cylinders about 1-3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled.

EXAMPLE 17 Solution

5-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,3-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester: 5%

dimethylformamide: 95%

The ingredients are combined and stirred to produce a solution, which can be used for low volume applications.

All compounds of the invention may be formulated in the same manner.

UTILITY

The compounds of the present invention are active herbicides. They have utility for broad-spectrum pre- and/or post-emergence weed control in areas where complete control of all vegetation is desired, such as around fuel storage tanks, ammunition depots, industrial storage areas, parking lots, drive-in theaters, around billboards, highway and railroad structures. Alternatively, some of the subject compounds are useful for the selective control of weeds in wheat, rice or cotton and for plant growth modification, such as growth retardation.

The rates of application for the compounds of the invention are determined by a number of factors, including their use as plant growth modifiers or general herbicides, the crop species involved, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.05 to 10 kg/ha, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, or for situations where only shortterm persistence is required.

The compounds of the invention may be used in combination with any other commercial herbicide; examples of which are those of the triazine, triazole, uracil, urea, amide, diphenylether, carbamate and bipyridylium types and mefluidide.

The herbicidal and plant growth modifying properties of the subject compounds were discovered in greenhouse tests. The test procedures and results follow.

Test A

Seeds of crabgrass (Digitaria sp.), barnyardgrass (Echinochloa crusgalli), wild oats (Avena fatua), sicklepod (Cassia obtusifolia), morningglory (Ipomoea sp.), cocklebur (Xanthium pensylvanicum), sorghum, corn, soybean, sugar beet, rice, wheat, cotton and purple nutsedge (Cyperus rotundus) tubers were planted and treated pre-emergence with the test chemicals dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species were treated post-emergence with a soil/foliage application. At the time of treatment, the plants ranged in height from 2 to 18 cm. Treated plants and controls were maintained in a greenhouse for sixteen days, after which all species were compared to controls and visually rated for response to treatment. The ratings, summarized in Table A, are based on a numerical scale extending from O=no injury, to 10=complete kill. The accompanying descriptive symbols have the following meanings:

C=chlorosis or necrosis;

E=emergence inhibition;

G=growth retardation; and

H=formative effects.

The data indicate that at the low rates of application selected for these evaluations, the compounds tested are active herbicides. Additionally, they often possess plant growth modifying properties, such as causing growth retardation.

    ______________________________________                                         Compounds                                                                      ______________________________________                                          ##STR41##                Compound 1                                            ##STR42##                Compound 2                                            ##STR43##                Compound 3                                            ##STR44##                Compound 4                                            ##STR45##                Compound 5                                            ##STR46##                Compound 6                                            ##STR47##                Compound 7                                            ##STR48##                Compound 8                                            ##STR49##                Compound 9                                            ##STR50##                Compound 10                                           ##STR51##                Compound 11                                           ##STR52##                Compound 12                                           ##STR53##                Compound 13                                           ##STR54##                Compound 14                                           ##STR55##                Compound 15                                           ##STR56##                Compound 16                                          ______________________________________                                    

                                      TABLE A                                      __________________________________________________________________________                                                       Cmpd.                                                                               Cmpd.                                                                              Cmpd.                       Compound 1   Compound 2   Compound 3                                                                              Compound 4                                                                            5    6   7                   Rate kg/ha                                                                             2.0 0.4  0.05                                                                               2.0 0.4  0.05                                                                               0.4 0.05 0.4 0.05                                                                              0.4                                                                              2.0                                                                               0.4 0.4                 __________________________________________________________________________     POST-EMERGENCE                                                                 Morningglory                                                                           5C,9G                                                                              2C,8G                                                                               4G  9C  9C   9C  4C,9G                                                                              3C,6H                                                                               2C,2H                                                                              2H 0 0  5C,8H                                                                              2C,3H               Cocklebur                                                                              2C,8G                                                                              1C   0   3H  5G   1H  2C,5H                                                                              0    0   0  0 0  0   3G                  Sicklepod                                                                              2C,9H                                                                              3C,7H                                                                               3C,5G                                                                              5C,6G                                                                              3C,4H                                                                               4C,4H                                                                              3C,8H                                                                              3C,3H                                                                               0   0  0 -- 0   0                   Nutsedge                                                                               8G  5G   7G  8G  8G   8G  3G  4G   0   0  0 0  0   0                   Crabgrass                                                                              6G  2G   0   4G  2G   0   1C  0    0   0  0 0  0   0                   Barnyardgrass                                                                          3C,8H                                                                              3C,8H                                                                               2C,5H                                                                              5C,9H                                                                              3C,9H                                                                               2C,3H                                                                              0   0    0   0  0 0  2C,4H                                                                              2C,5H               Wild Oats                                                                              2C,5G                                                                              0    0   2G  0    0   0   0    0   0  0 0  0   0                   Wheat   4G  0    0   0   0    0   0   0    0   0  0 0  3G  0                   Corn    2C,9G                                                                              3C,8G                                                                               3C,8H                                                                              2C,8H                                                                              3C,8H                                                                               2C,5H                                                                              0   0    0   0  0 0  3C,8H                                                                              2C,5H               Soybean 3C,9H                                                                              4C,8H                                                                               3C,9G                                                                              4C,9G                                                                              5C,9G                                                                               3C,7G                                                                              2C,8G                                                                              2C,2H                                                                               0   0  0 0  2C,3H                                                                              2C,3H               Rice    2G  2G   0   2C,7G                                                                              2C,7G                                                                               4G  0   0    0   0  0 0  4C,8G                                                                              2C,6G               Sorghum 3C,8H                                                                              3C,8H                                                                               3C,8H                                                                              3C,8H                                                                              3C,7G                                                                               5G  3C,5G                                                                              2G   0   0  0 0  5C,9H                                                                              3C,5H               Sugar beet                                                                             3C,7G                                                                              3C,5G                                                                               3G  3C,8H                                                                              1C,4G                                                                               4G  3C,6G                                                                              2C,3G                                                                               1C,1H                                                                              0  0 0  4C,8H                                                                              3C,6H               Cotton  3C,9G                                                                              4C,7G                                                                               3C,5H                                                                              4C,8G                                                                              3C,8G                                                                               2C,7G                                                                              3C,8H                                                                              0    0   0  0 0  4G  2H                  PRE-EMERGENCE                                                                  Morningglory                                                                           5C,9G                                                                              4C,7G                                                                               3H  9C  9G   8G  2C,5H                                                                              0    1C  0  0 0  2C  0                   Cocklebur                                                                              --  0    5H  9H  8H   0   0   0    0   0  0 0  0   0                   Sicklepod                                                                              4C,8G                                                                              4C,6G                                                                               3G  9G  --   8G  2C  0    0   0  0 -- 0   0                   Nutsedge                                                                               10E 0    0   10E 10E  0   10E 0    0   0  0 0  0   0                   Crabgrass                                                                              6G  2C,5G                                                                               2C,3G                                                                              4G  3G   0   0   0    0   0  0 0  0   0                   Barnyardgrass                                                                          4C,9H                                                                              2C,5G                                                                               0   4C,9H                                                                              3C,8H                                                                               3G  0   0    0   0  0 0  0   0                   Wild Oats                                                                              4C,8G                                                                              2C,3G                                                                               0   2C,6G                                                                              1C,3G                                                                               2G  0   0    0   0  0 0  0   0                   Wheat   8G  3G   0   2C,8H                                                                              4G   0   0   0    0   0  0 0  2G  0                   Corn    5C,9G                                                                              4C,5G                                                                               2C,2G                                                                              2C,9H                                                                              4C,9H                                                                               2C  2C  0    3G  0  0 0  3G  0                   Soybean 3C,5H                                                                              2C,2H                                                                               1C  4C,7G                                                                              3C,3H                                                                               0   2C,3H                                                                              0    0   0  0 0  1C  0                   Rice    3C,8H                                                                              2C,5G                                                                               0   10E 4C,9H                                                                               2C  0   0    0   0  0 0  2C  0                   Sorghum 3C,9H                                                                              3C,8G                                                                               2C,3G                                                                              6G,9H                                                                              4C,9G                                                                               2C,3H                                                                              4C,5G                                                                              0    0   0  0 0  2C,5G                                                                              2C,6G               Sugar beet                                                                             4C,8G                                                                              3C,8G                                                                               2C,4G                                                                              5C,9G                                                                              9G   7G  3C,8G                                                                              2C   2C,3G                                                                              0  0 0  0   0                   Cotton  2C  0    0   9G  2C,8G                                                                               0   4G  0    0   0  0 0  0   0                   __________________________________________________________________________                 Com-                                                                       Cmpd.                                                                              pound        Cmpd.        Cmpd.                                                                               Cmpd.                                       8   9    Compound 10                                                                            11   Cmpd. 12                                                                               13   14  Compound                                                                                Compound 16            Rate (kg/ha)                                                                           0.4 0.4  0.4 0.05                                                                               0.4  0.4 2.0 0.4  0.4 0.4 2.0  0.4                                                                               2.0                 __________________________________________________________________________     POSTEMERGENCE                                                                  Morningglory                                                                           3C,5G                                                                              2C,3H                                                                               4C,5G                                                                              8G,2C                                                                              3C,7H                                                                               1C  0   2C,9G                                                                               5C,9G                                                                              1C  0    0  0                   Cocklebur                                                                              0   0    1H  0   4C,9H                                                                               2C,5G                                                                              6H  0    5C,9G                                                                              3C,8H                                                                              2C,7H                                                                               0  0                   Nutsedge                                                                               0   0    2C,8G                                                                              2C,5G                                                                              0    0   0   3G   5G  0   0    0  0                   Crabgrass                                                                              0   0    4H  0   0    0   0   2G   4G  0   0    0  0                   Barnyardgrass                                                                          0   0    1H  0   0    0   0   2H   2G  0   0    0  0                   Wild Oats                                                                              0   0    0   0   0    0   0   0    0   0   0    0  0                   Wheat   0   0    0   0   0    0   0   0    2G  0   0    0  0                   Corn    0   0    0   0   0    0   0   2H   2C,8H                                                                              0   2H   0  0                   Soybean 3C,6G                                                                              3C,7G                                                                               3C,8G                                                                              2C,9G                                                                              3C,8G                                                                               0   2C,5G                                                                              3C,9G                                                                               4C,9G                                                                              0   0    0  0                   Rice    4G  3G   2C,3G                                                                              2G  0    0   0   3C,9G                                                                               2C,8H                                                                              0   0    0  0                   Sorghum 3G  3C,5H                                                                               2C,2H                                                                              0   0    0   0   2C,9H                                                                               3C,9G                                                                              0   0    0  0                   Sugar Beets                                                                            3C,6G                                                                              2C   5C,8H                                                                              1C,4G                                                                              2C,2G                                                                               0   2H  9C   9C  0   0    0  0                   Cotton  0   0    3C,7G                                                                              2C,5G                                                                              3G   0   0   4C,9G                                                                               3C,8G                                                                              0   2H   0  0                   Cassia  1C  0    2C,5G                                                                              0   2C   0   --  2C,3G                                                                               4C,6G                                                                              0   0    0  --                  PREEMERGENCE                                                                   Morningglory                                                                           0   0    9G  7G  8G   0   4H  2C,8H                                                                               9G  1C  7G   0  0                   Cocklebur                                                                              0   0    2G  0   3C,6G                                                                               0   3H  0    9H  2C,5H                                                                              5H   0  0                   Nutsedge                                                                               0   0    8G  5G  0    0   0   2G   2G  0   0    0  0                   Crabgrass                                                                              0   0    2G  0   0    0   0   0    0   0   0    0  0                   Barnyardgrass                                                                          0   0    4G  1C  0    0   0   6H   5H  0   0    0  0                   Wild Oats                                                                              0   0    2G  0   0    0   0   2C,4G                                                                               2G  0   0    0  0                   Wheat   0   0    0   0   0    0   0   8G   4G  0   0    0  0                   Corn    0   0    2C,8H                                                                              2C,5G                                                                              2C,4G                                                                               0   0   2C,8G                                                                               9G  0   0    0  0                   Soybean 0   0    2C  0   0    0   0   2C,3H                                                                               2C,4H                                                                              0   0    0  0                   Rice    0   0    4G  2G  0    0   0   3C,5G                                                                               2C,2G                                                                              0   0    0  0                   Sorghum 0   0    2C,7G                                                                              3G  2C,3G                                                                               0   0   2C,9H                                                                               9H  0   0    0  0                   Sugar Beets                                                                            0   0    9G  4G  8G   0   4H  5C,9G                                                                               5C,9G                                                                              0   0    0  0                   Cotton  0   0    5G  0   0    0   0   2C,4G                                                                               5G  0   0    0  0                   Cassia  0   0    2C,7G                                                                              0   0    0   --  1C   3C,5G                                                                              0   --   0  --                  __________________________________________________________________________ 

What is claimed is:
 1. A compound of formula: ##STR57## wherein J is ##STR58## R is H or CH₃ ; R₉ is H, C₁ -C₃ alkyl or phenyl;R₁₀ is CO₂ R₁₅, C(O)NR₁₆ R₁₇, SO₂ NR₁₆ R₁₇, SO₂ N(OCH₃)CH₃, SO₂ R₁₈ or NO₂ ; R₁₁ is H or CH₃ ; R₁₂ is H, CO₂ R₁₅, C(O)NR₁₆ R₁₇, SO₂ NR₁₆ R₁₇, SO₂ N(OCH₃)CH₃, SO₂ R₁₈ or NO₂ ; R₁₃ is H, CO₂ R₁₅, C(O)NR₁₆ R₁₇, SO₂ NR₁₆ R₁₇, SO₂ N(OCH₃)CH₃, SO₂ R₁₈ or NO₂ ; R₁₄ is H or CH₃ ; R₁₅ is C₁ -C₂ alkyl; R₁₆ is H or C₁ -C₂ alkyl; R₁₇ is H or C₁ -C₂ alkyl; R₁₈ is C₁ -C₂ alkyl; A is ##STR59## X is CH₃, OCH₃, Cl, Br, OCH₂ CF₃ or OCHF₂ ; Y is C₁ -C₃ alkyl, CH₂ F, cyclopropyl, C.tbd.CH, OCH₃, OC₂ H₅, CH₂ OCH₃, NH₂, NHCH₃, N(CH₃)₂, OCH₂ CH₂ F, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CR(OCH₃)₂, ##STR60## CR(OCH₂ CH₃)₂ or OCF₂ H; Z is CH;provided that (1) when X is Cl or Br, then Y is OCH₃, OC₂ H₅, NHCH₃, N(CH₃)₂ or OCF₂ H; (2) R₁₂ and R₁₃ are not simultaneously H; and (3) when R₁₂ is other than H, then R₁₃ must be H.
 2. Compounds of claim 1 where R is H, X is CH₃ or OCH₃ and Y is C₁ -C₂ alkyl or C₁ -C₂ alkoxy.
 3. Compounds of claim 2 where J is J-4.
 4. Compounds of claim 2 where J is J-5.
 5. Compounds of claim 2 where J is J-6.
 6. The compound of claim 1 which is 3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,5-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester.
 7. The compound of claim 1 which is 5-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonylmethyl]-1,3-dimethyl-1H-pyrazole-4-carboxylic acid, ethyl ester.
 8. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 1 and at least one of the following: surfactant, solid or liquid diluent.
 9. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 2 and at least one of the following: surfactant, solid or liquid diluent.
 10. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 3 and at least one of the following: surfactant, solid or liquid diluent.
 11. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 4 and at least one of the following: surfactant, solid or liquid diluent.
 12. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 5 and at least one of the following: surfactant, solid or liquid diluent.
 13. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 6 and at least one of the following: surfactant, solid or liquid diluent.
 14. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 7 and at least one of the following: surfactant, solid or liquid diluent.
 15. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 1. 16. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 2. 17. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 3. 18. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 4. 19. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 5. 20. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim
 6. 21. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim
 7. 